HCSGD entry for RNMT
1. General information
| Official gene symbol | RNMT |
|---|---|
| Entrez ID | 8731 |
| Gene full name | RNA (guanine-7-) methyltransferase |
| Other gene symbols | MET RG7MT1 hCMT1c |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001510 | RNA methylation | IDA IMP TAS | biological_process |
| GO:0003723 | RNA binding | IMP | molecular_function |
| GO:0004482 | MRNA (guanine-N7-)-methyltransferase activity | IDA IEA IMP TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005845 | MRNA cap binding complex | IDA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006370 | 7-methylguanosine mRNA capping | IMP TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0036265 | RNA (guanine-N7)-methylation | IDA IMP TAS | biological_process |
| GO:0043235 | Receptor complex | IDA | cellular_component |
| GO:0080009 | MRNA methylation | IDA IMP TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0325083090 | 0.9102837886 | 0.4163752798 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2434851788 |
| GSE13712_SHEAR | Down | -0.3777001944 |
| GSE13712_STATIC | Down | -0.1680834746 |
| GSE19018 | Up | 0.3793899634 |
| GSE19899_A1 | Up | 0.3640143945 |
| GSE19899_A2 | Up | 0.8780964531 |
| PubMed_21979375_A1 | Down | -0.0990827774 |
| PubMed_21979375_A2 | Up | 1.6512240929 |
| GSE35957 | Up | 0.0223218772 |
| GSE36640 | Down | -0.1212145715 |
| GSE54402 | Up | 0.5530536818 |
| GSE9593 | Up | 0.0604322560 |
| GSE43922 | Up | 0.1657147116 |
| GSE24585 | Down | -0.3932867775 |
| GSE37065 | Up | 0.2105537952 |
| GSE28863_A1 | Up | 0.2822301937 |
| GSE28863_A2 | Up | 0.4318558404 |
| GSE28863_A3 | Down | -0.1733523741 |
| GSE28863_A4 | Down | -0.0681232454 |
| GSE48662 | Up | 0.1163025316 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027113 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031646 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032372 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-484 | MIMAT0002174 | MIRT042067 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043402 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051661 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | 2 | hsa-miR-1 | {Western blot} | {overexpression by miRNA precursor transfection} | 18818206 | |
| hsa-miR-1 | MIMAT0000416 | 1 | hsa-miR-1 | {Western blot} | {overexpression by miRNA precursor transfection} | 18818206 | |
| hsa-miR-34a-5p | MIMAT0000255 | 2 | hsa-miR-34a | {Western blot} | {overexpression by miRNA precursor transfection} | 19773441 | |
| hsa-miR-34a-5p | MIMAT0000255 | 1 | hsa-miR-34a | {Western blot} | {overexpression by miRNA precursor transfection} | 19773441 | |
| hsa-miR-206 | MIMAT0000462 | 2 | hsa-miR-206 | 19710019 | |||
| hsa-miR-206 | MIMAT0000462 | 1 | hsa-miR-206 | 19710019 | |||
| hsa-miR-1 | MIMAT0000416 | 2 | hsa-miR-1 | 19710019 | |||
| hsa-miR-1 | MIMAT0000416 | 1 | hsa-miR-1 | 19710019 | |||
| hsa-miR-23b-3p | MIMAT0000418 | 2 | hsa-miR-23b | {Western blot} | {overexpression by miRNA mimics tranfection} | 19490101 | |
| hsa-miR-23b-3p | MIMAT0000418 | 3 | hsa-miR-23b | {Western blot} | {overexpression by miRNA mimics tranfection} | 19490101 | |
| hsa-miR-23b-3p | MIMAT0000418 | 4 | hsa-miR-23b | {Western blot} | {overexpression by miRNA mimics tranfection} | 19490101 | |
| hsa-miR-23b-3p | MIMAT0000418 | 1 | hsa-miR-23b | {Western blot} | {overexpression by miRNA mimics tranfection} | 19490101 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26992231 | RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence |
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