HCSGD entry for TNK1
1. General information
| Official gene symbol | TNK1 |
|---|---|
| Entrez ID | 8711 |
| Gene full name | tyrosine kinase, non-receptor, 1 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004713 | Protein tyrosine kinase activity | IDA | molecular_function |
| GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | NAS | molecular_function |
| GO:0004871 | Signal transducer activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IDA TAS | biological_process |
| GO:0030308 | Negative regulation of cell growth | IEA | biological_process |
| GO:0046580 | Negative regulation of Ras protein signal transduction | IEA | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8605840470 | 0.4883554348 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1045504396 |
| GSE13712_SHEAR | Down | -0.2535466063 |
| GSE13712_STATIC | Down | -0.0716369235 |
| GSE19018 | Up | 0.1055669127 |
| GSE19899_A1 | Up | 0.0369981565 |
| GSE19899_A2 | Down | -0.0107748937 |
| PubMed_21979375_A1 | Down | -0.2210766228 |
| PubMed_21979375_A2 | Down | -0.2892257486 |
| GSE35957 | Down | -0.0399286417 |
| GSE36640 | Up | 0.0946073768 |
| GSE54402 | Down | -0.1558663887 |
| GSE9593 | Down | -0.1029004050 |
| GSE43922 | Up | 0.0538841769 |
| GSE24585 | Down | -0.0098762340 |
| GSE37065 | Down | -0.0064881667 |
| GSE28863_A1 | Up | 0.0700778225 |
| GSE28863_A2 | Down | -0.1064279739 |
| GSE28863_A3 | Up | 0.3192135047 |
| GSE28863_A4 | Up | 0.1132716145 |
| GSE48662 | Up | 0.0984237968 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT051086 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
