HCSGD entry for DGAT1
1. General information
| Official gene symbol | DGAT1 |
|---|---|
| Entrez ID | 8694 |
| Gene full name | diacylglycerol O-acyltransferase 1 |
| Other gene symbols | ARAT ARGP1 DGAT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003846 | 2-acylglycerol O-acyltransferase activity | IEA | molecular_function |
| GO:0004144 | Diacylglycerol O-acyltransferase activity | EXP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006641 | Triglyceride metabolic process | TAS | biological_process |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0008374 | O-acyltransferase activity | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | ISS | cellular_component |
| GO:0016746 | Transferase activity, transferring acyl groups | TAS | molecular_function |
| GO:0019432 | Triglyceride biosynthetic process | IDA TAS | biological_process |
| GO:0019915 | Lipid storage | ISS | biological_process |
| GO:0034379 | Very-low-density lipoprotein particle assembly | IMP | biological_process |
| GO:0035336 | Long-chain fatty-acyl-CoA metabolic process | ISS | biological_process |
| GO:0036155 | Acylglycerol acyl-chain remodeling | TAS | biological_process |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046339 | Diacylglycerol metabolic process | ISS | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
| GO:0050252 | Retinol O-fatty-acyltransferase activity | IEA | molecular_function |
| GO:0055089 | Fatty acid homeostasis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0921386346 | 0.6454507010 | 0.6382055263 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0281583559 |
| GSE13712_SHEAR | Down | -0.0723424291 |
| GSE13712_STATIC | Up | 0.0190640914 |
| GSE19018 | Down | -0.0182677872 |
| GSE19899_A1 | Down | -0.2279828160 |
| GSE19899_A2 | Up | 0.3725448026 |
| PubMed_21979375_A1 | Up | 1.6398701703 |
| PubMed_21979375_A2 | Up | 1.4256778991 |
| GSE35957 | Down | -0.5403593613 |
| GSE36640 | Up | 0.3119730795 |
| GSE54402 | Up | 0.1337393833 |
| GSE9593 | Down | -0.2742848312 |
| GSE43922 | Up | 0.0011887403 |
| GSE24585 | Up | 0.3102128368 |
| GSE37065 | Down | -0.0566357721 |
| GSE28863_A1 | Down | -0.3924167045 |
| GSE28863_A2 | Up | 0.1283554348 |
| GSE28863_A3 | Up | 0.2404893359 |
| GSE28863_A4 | Up | 0.1690872024 |
| GSE48662 | Up | 0.1519583133 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | MIRT006524 | Luciferase reporter assay | Functional MTI | 19635812 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029044 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-484 | MIMAT0002174 | MIRT042201 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047045 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
