HCSGD entry for HYAL2

1. General information

Official gene symbolHYAL2
Entrez ID8692
Gene full namehyaluronoglucosaminidase 2
Other gene symbolsLUCA2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneISScellular_component
GO:0000302Response to reactive oxygen speciesIDAbiological_process
GO:0001618Virus receptor activityIDA IEAmolecular_function
GO:0001822Kidney developmentISSbiological_process
GO:0002244Hematopoietic progenitor cell differentiationIEAbiological_process
GO:0004415Hyalurononglucosaminidase activityIDA IEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005540Hyaluronic acid bindingIDAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005764LysosomeIDAcellular_component
GO:0005783Endoplasmic reticulumNAScellular_component
GO:0005829CytosolIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005902MicrovillusIDAcellular_component
GO:0005975Carbohydrate metabolic processIEA TASbiological_process
GO:0006027Glycosaminoglycan catabolic processIDAbiological_process
GO:0009615Response to virusIDAbiological_process
GO:0009986Cell surfaceIDA ISScellular_component
GO:0010259Multicellular organismal agingIEAbiological_process
GO:0010764Negative regulation of fibroblast migrationIDAbiological_process
GO:0016023Cytoplasmic membrane-bounded vesicleIDAcellular_component
GO:0016324Apical plasma membraneIDAcellular_component
GO:0019064Fusion of virus membrane with host plasma membraneIDAbiological_process
GO:0019087Transformation of host cell by virusIDA ISSbiological_process
GO:0019899Enzyme bindingIEA IPImolecular_function
GO:0030139Endocytic vesicleIDAcellular_component
GO:0030203Glycosaminoglycan metabolic processTASbiological_process
GO:0030212Hyaluronan metabolic processTASbiological_process
GO:0030214Hyaluronan catabolic processIDA TASbiological_process
GO:0030294Receptor signaling protein tyrosine kinase inhibitor activityIDAmolecular_function
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0030971Receptor tyrosine kinase bindingIPImolecular_function
GO:0031362Anchored component of external side of plasma membraneIDA IEAcellular_component
GO:0031410Cytoplasmic vesicleIDAcellular_component
GO:0033906Hyaluronoglucuronidase activityIDAmolecular_function
GO:0035810Positive regulation of urine volumeISSbiological_process
GO:0042117Monocyte activationIDAbiological_process
GO:0042307Positive regulation of protein import into nucleusIEA ISSbiological_process
GO:0043407Negative regulation of MAP kinase activityIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0044344Cellular response to fibroblast growth factor stimulusIDAbiological_process
GO:0045121Membrane raftIDA IEAcellular_component
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0046658Anchored component of plasma membraneIDAcellular_component
GO:0046677Response to antibioticIEPbiological_process
GO:0046718Viral entry into host cellISSbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048705Skeletal system morphogenesisIEAbiological_process
GO:0050431Transforming growth factor beta bindingIEA ISSmolecular_function
GO:0050729Positive regulation of inflammatory responseIDAbiological_process
GO:0051216Cartilage developmentIEPbiological_process
GO:0051607Defense response to virusIEAbiological_process
GO:0051898Negative regulation of protein kinase B signalingIDAbiological_process
GO:0060586Multicellular organismal iron ion homeostasisIEAbiological_process
GO:0061099Negative regulation of protein tyrosine kinase activityIDAbiological_process
GO:0070295Renal water absorptionISSbiological_process
GO:0071347Cellular response to interleukin-1IDAbiological_process
GO:0071356Cellular response to tumor necrosis factorIEPbiological_process
GO:0071493Cellular response to UV-BIDAbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIDA IEAbiological_process
GO:2000484Positive regulation of interleukin-8 secretionIDAbiological_process
GO:2000778Positive regulation of interleukin-6 secretionIDAbiological_process
GO:2001238Positive regulation of extrinsic apoptotic signaling pathwayIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.46033823940.45057259220.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4132858612
GSE13712_SHEARUp0.1437004093
GSE13712_STATICUp0.2103217957
GSE19018Down-0.7711249773
GSE19899_A1Down-0.4223192556
GSE19899_A2Down-0.2797658073
PubMed_21979375_A1Up0.8096482176
PubMed_21979375_A2Down-0.1235488576
GSE35957Down-0.0701424878
GSE36640Up0.4473187266
GSE54402Down-0.0016584028
GSE9593Down-0.0833662480
GSE43922Up0.0629718318
GSE24585Down-0.0875807791
GSE37065Up0.0167997016
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.0838386112

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.