HCSGD entry for BECN1

1. General information

Official gene symbolBECN1
Entrez ID8678
Gene full namebeclin 1, autophagy related
Other gene symbolsATG6 VPS30 beclin1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000045Autophagic vacuole assemblyIEAbiological_process
GO:0000910CytokinesisIMPbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005802Trans-Golgi networkIEAcellular_component
GO:0006914AutophagyIEAbiological_process
GO:0006968Cellular defense responseTASbiological_process
GO:0007040Lysosome organizationIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016023Cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0016032Viral processIEAbiological_process
GO:0016239Positive regulation of macroautophagyIEAbiological_process
GO:0030425DendriteIEAcellular_component
GO:0033197Response to vitamin EIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0048666Neuron developmentIEAbiological_process
GO:0050435Beta-amyloid metabolic processIEAbiological_process
GO:0051607Defense response to virusIEAbiological_process
GO:0051707Response to other organismIEAbiological_process
GO:0060548Negative regulation of cell deathIEAbiological_process
GO:0071275Cellular response to aluminum ionIEAbiological_process
GO:0071364Cellular response to epidermal growth factor stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18049396680.95512977090.83235826331.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3050137306
GSE13712_SHEARDown-0.0923896671
GSE13712_STATICDown-0.1541432209
GSE19018Up0.1838748631
GSE19899_A1Down-0.1068801165
GSE19899_A2Up0.1247630648
PubMed_21979375_A1Down-0.0739953752
PubMed_21979375_A2Up0.3125546620
GSE35957Up0.2947333915
GSE36640Up0.3292802423
GSE54402Up0.1830861019
GSE9593Up0.2869227402
GSE43922Down-0.1612443981
GSE24585Up0.3192214349
GSE37065Up0.1925129959
GSE28863_A1Up0.0789795255
GSE28863_A2Up0.0927687013
GSE28863_A3Down-0.2088447068
GSE28863_A4Up0.1100343670
GSE48662Up0.0497804033

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT004509Luciferase reporter assay//Reporter assay;OtherFunctional MTI19535919
hsa-miR-100-5pMIMAT0000098MIRT048553CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26930622We evaluated cell toxicity, apoptosis, viability, proliferation, senescence and autophagy in response to APAP (acetaminophen), cisplatin, dexamethasone, gentamicin, penicillin, neomycin, streptomycin, and tobramycin, at five different doses and two time-points (24 and 48 h), by flow cytometry techniques and caspase 3/7, MTT, Cytotoxicity, BrdU, Beclin1, LC3 and SA-beta-galactosidase assays
26159917Additionally, the cellular senescence phenotypes were manifested at the molecular level by a significant increase in p21 and p53 expression, a decrease in SOD2 expression, and a decrease in expression of some key autophagy-related genes such as Atg5, Atg7, Atg12, and Beclin 1
26159917Furthermore, we found that the senescence-like phenotype of MPTP-treated hNPCs was rejuvenated through treatment with a well-known autophagy enhancer rapamycin, which was blocked by suppression of essential autophagy gene Beclin 1
25186470Knockdown of FOXO1 and FOXO1+3 resulted in significant reductions in levels of glutathione peroxidase 1 (GPX-1), catalase, light chain 3 (LC3), Beclin1, and sirtuin 1 (SIRT-1) proteins following treatment with tBHP
25186470In contrast, the constitutive active form of FOXO3 increased cell viability while inducing GPX-1, Beclin1, and LC3 in response to tBHP
23220384Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process
23220384Beclin 1 is a platform protein which assembles an interactome consisting of diverse proteins which control the initiation of autophagocytosis and distinct phases in endocytosis
23220384Recent studies have demonstrated that the anti-apoptotic Bcl-2 family members can interact with Beclin 1 and inhibit autophagy
23220384We will review the role of Beclin 1 interactome in the crosstalk between apoptosis, autophagy and inflammasomes emphasizing that disturbances in Beclin 1-dependent autophagy can have a crucial impact on the aging process
22899934IKK complex and NF-kappaB can enhance the expression of Beclin 1 and other autophagy-related proteins and stimulate autophagy whereas as a feedback response, autophagy can degrade IKK components
22551517Western blot revealed senescent DPCs had greater expression of autophagic proteins (microtubule-associated protein light chain 3 and Beclin 1) than young cells (P = 0
22551517CONCLUSIONS: Expression of autophagic proteins (microtubule-associated protein light chain 3 and Beclin 1) increased in senescent DPCs compare to young cells
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