HCSGD entry for EIF3C
1. General information
| Official gene symbol | EIF3C |
|---|---|
| Entrez ID | 8663 |
| Gene full name | eukaryotic translation initiation factor 3, subunit C |
| Other gene symbols | EIF3CL EIF3S8 eIF3-p110 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001731 | Formation of translation preinitiation complex | IEA | biological_process |
| GO:0003743 | Translation initiation factor activity | IC IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005852 | Eukaryotic translation initiation factor 3 complex | IDA IEA | cellular_component |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006413 | Translational initiation | IC IDA TAS | biological_process |
| GO:0006446 | Regulation of translational initiation | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016282 | Eukaryotic 43S preinitiation complex | IEA | cellular_component |
| GO:0031369 | Translation initiation factor binding | IEA | molecular_function |
| GO:0033290 | Eukaryotic 48S preinitiation complex | IEA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7165057255 | 0.0269556020 | 0.9999902473 | 0.3137899646 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3748053619 |
| GSE13712_SHEAR | Up | 0.1774837537 |
| GSE13712_STATIC | Up | 0.1317632026 |
| GSE19018 | Down | -0.3554719240 |
| GSE19899_A1 | Up | 0.0084053404 |
| GSE19899_A2 | Down | -0.1727175423 |
| PubMed_21979375_A1 | Down | -0.4722421016 |
| PubMed_21979375_A2 | Down | -0.8292960925 |
| GSE35957 | Down | -0.2283734898 |
| GSE36640 | Up | 0.0503837585 |
| GSE54402 | Up | 0.0969464140 |
| GSE9593 | Up | 0.0335710478 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.5267210975 |
| GSE28863_A2 | Down | -1.0577408849 |
| GSE28863_A3 | Down | -0.5156544881 |
| GSE28863_A4 | Up | 0.0181433618 |
| GSE48662 | Down | -0.3292029516 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020535 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031415 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-320c | MIMAT0005793 | MIRT036164 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036476 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036996 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99b-3p | MIMAT0004678 | MIRT038530 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-425-5p | MIMAT0003393 | MIRT039309 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039669 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042529 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044100 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044779 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044937 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045450 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047297 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049027 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT051357 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051775 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051944 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052417 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
