HCSGD entry for IRS2

1. General information

Official gene symbolIRS2
Entrez ID8660
Gene full nameinsulin receptor substrate 2
Other gene symbolsIRS-2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002053Positive regulation of mesenchymal cell proliferationIEAbiological_process
GO:0002903Negative regulation of B cell apoptotic processISSbiological_process
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005158Insulin receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006006Glucose metabolic processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0008284Positive regulation of cell proliferationNASbiological_process
GO:0008286Insulin receptor signaling pathwayISS TASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009749Response to glucoseISSbiological_process
GO:0010748Negative regulation of plasma membrane long-chain fatty acid transportIMPbiological_process
GO:0010907Positive regulation of glucose metabolic processIMPbiological_process
GO:0019216Regulation of lipid metabolic processTASbiological_process
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0019903Protein phosphatase bindingIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030335Positive regulation of cell migrationIEAbiological_process
GO:0030879Mammary gland developmentIEAbiological_process
GO:0030890Positive regulation of B cell proliferationISSbiological_process
GO:0032000Positive regulation of fatty acid beta-oxidationIMPbiological_process
GO:0032024Positive regulation of insulin secretionISSbiological_process
GO:0032869Cellular response to insulin stimulusIMPbiological_process
GO:0033673Negative regulation of kinase activityISSbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0043548Phosphatidylinositol 3-kinase bindingIEAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045725Positive regulation of glycogen biosynthetic processIMP NASbiological_process
GO:0046326Positive regulation of glucose importIMPbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0055088Lipid homeostasisTASbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTASbiological_process
GO:0071333Cellular response to glucose stimulusIEAbiological_process
GO:007188914-3-3 protein bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.14817712850.02439539910.77110618580.3004732335

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.1396234631
GSE13712_SHEARUp0.8169560855
GSE13712_STATICDown-0.9587129192
GSE19018Up0.3850913619
GSE19899_A1Down-0.5263255648
GSE19899_A2Down-0.2717706018
PubMed_21979375_A1Down-0.6433180811
PubMed_21979375_A2Down-0.8425705577
GSE35957Up1.5742586717
GSE36640Up0.2137852827
GSE54402Down-0.0723408801
GSE9593Up0.9132610478
GSE43922Down-0.1180322121
GSE24585Down-0.0939151618
GSE37065Up0.0665297912
GSE28863_A1Down-0.3653815020
GSE28863_A2Down-0.2234256144
GSE28863_A3Up0.3963066564
GSE28863_A4Down-0.1354656438
GSE48662Up0.1284584710

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-145-5pMIMAT0000437MIRT006332Luciferase reporter assayFunctional MTI22431718
hsa-miR-7-5pMIMAT0000252MIRT003808Reporter assay//Western blot//Reporter assay;Western blotFunctional MTI18483236
hsa-miR-33a-5pMIMAT0000091MIRT007355Immunofluorescence//Luciferase reporter assay//Western blotFunctional MTI23547260
hsa-miR-374b-5pMIMAT0004955MIRT016052SequencingFunctional MTI (Weak)20371350
hsa-miR-98-5pMIMAT0000096MIRT027863MicroarrayFunctional MTI (Weak)19088304
hsa-miR-484MIMAT0002174MIRT041990CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051561CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052219CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-7-5pMIMAT00002521hsa-miR-7{Western blot}{overexpression by miRNA precursor transfection}18483236
hsa-miR-7-5pMIMAT00002522hsa-miR-7{Western blot}{overexpression by miRNA precursor transfection}18483236
hsa-miR-7-5pMIMAT0000252NAhsa-miR-7{Western blot}{overexpression by miRNA precursor transfection}21156648
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.