HCSGD entry for DYNLL1

1. General information

Official gene symbolDYNLL1
Entrez ID8655
Gene full namedynein, light chain, LC8-type 1
Other gene symbolsDLC1 DLC8 DNCL1 DNCLC1 LC8 LC8a PIN hdlc1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000776KinetochoreIDAcellular_component
GO:0003774Motor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0005868Cytoplasmic dynein complexISScellular_component
GO:0005874MicrotubuleIEAcellular_component
GO:0005875Microtubule associated complexIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006810TransportIEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0007017Microtubule-based processIEAbiological_process
GO:0007292Female gamete generationTASbiological_process
GO:0008022Protein C-terminus bindingIEAmolecular_function
GO:0008180COP9 signalosomeIDAcellular_component
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016032Viral processIEAbiological_process
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0019899Enzyme bindingIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030036Actin cytoskeleton organizationTASbiological_process
GO:0030235Nitric-oxide synthase regulator activityIEAmolecular_function
GO:0042326Negative regulation of phosphorylationIDAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0072686Mitotic spindleIDAcellular_component
GO:0097193Intrinsic apoptotic signaling pathwayTASbiological_process
GO:1900740Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.83608980280.38561466510.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1388569374
GSE13712_SHEARDown-0.0788512617
GSE13712_STATICDown-0.0408072224
GSE19018Down-0.4637031798
GSE19899_A1Up0.0769547540
GSE19899_A2Down-0.0457246002
PubMed_21979375_A1Up0.2192754209
PubMed_21979375_A2Up0.0804306990
GSE35957Down-0.3474447015
GSE36640Up0.1020206022
GSE54402Up0.0668905684
GSE9593Down-0.0396978368
GSE43922Down-0.0291809174
GSE24585Up0.1516333036
GSE37065Down-0.2290853142
GSE28863_A1Down-0.1431371919
GSE28863_A2Down-0.2200187339
GSE28863_A3Up0.1624711118
GSE28863_A4Up0.1747629093
GSE48662Down-0.2240539023

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-92a-3pMIMAT0000092MIRT049381CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.