HCSGD entry for PDE5A
1. General information
| Official gene symbol | PDE5A |
|---|---|
| Entrez ID | 8654 |
| Gene full name | phosphodiesterase 5A, cGMP-specific |
| Other gene symbols | CGB-PDE CN5A PDE5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | IEA NAS | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0010613 | Positive regulation of cardiac muscle hypertrophy | IEA | biological_process |
| GO:0030553 | CGMP binding | IEA TAS | molecular_function |
| GO:0042130 | Negative regulation of T cell proliferation | IEA | biological_process |
| GO:0043406 | Positive regulation of MAP kinase activity | IEA | biological_process |
| GO:0046068 | CGMP metabolic process | IEA | biological_process |
| GO:0046069 | CGMP catabolic process | IDA IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity | IEA | molecular_function |
| GO:0055118 | Negative regulation of cardiac muscle contraction | IEA | biological_process |
| GO:0055119 | Relaxation of cardiac muscle | IEA | biological_process |
| GO:0060282 | Positive regulation of oocyte development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7075076137 | 0.0015492914 | 0.9999902473 | 0.0760460111 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1944747567 |
| GSE13712_SHEAR | Up | 0.0091002482 |
| GSE13712_STATIC | Up | 0.0797576601 |
| GSE19018 | Down | -0.0083072137 |
| GSE19899_A1 | Down | -1.1625328848 |
| GSE19899_A2 | Down | -2.0762020284 |
| PubMed_21979375_A1 | Down | -3.3802922573 |
| PubMed_21979375_A2 | Down | -1.8980170822 |
| GSE35957 | Up | 0.6307106908 |
| GSE36640 | Up | 1.2883081130 |
| GSE54402 | Down | -1.6102152189 |
| GSE9593 | Up | 0.1416742309 |
| GSE43922 | Down | -1.7239430554 |
| GSE24585 | Down | -0.5686053397 |
| GSE37065 | Down | -0.7338195967 |
| GSE28863_A1 | Down | -0.0350212258 |
| GSE28863_A2 | Down | -0.1410649044 |
| GSE28863_A3 | Down | -0.3084767128 |
| GSE28863_A4 | Up | 0.0939121383 |
| GSE48662 | Up | 0.4575163600 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Sildenafil | DB00203 | APRD00556 |
| Theophylline | DB00277 | APRD00082 | DB09359 |
| Pentoxifylline | DB00806 | APRD00121 |
| Vardenafil | DB00862 | APRD00699 |
| Dipyridamole | DB00975 | APRD00360 |
| Guanosine-5'-Monophosphate | DB01972 | EXPT00246 |
| Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine | DB03597 | EXPT01826 |
| Citric Acid | DB04272 | EXPT00922 |
| OSI-461 | DB05415 | - |
| Avanafil | DB06237 | - |
| Udenafil | DB06267 | - |
| 3-isobutyl-1-methyl-7H-xanthine | DB07954 | - |
| 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide | DB08729 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017190 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26464516 | Senescent human VSMC showed elevated PDE1A and PDE1C and PDE5 mRNA levels (11 |
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