HCSGD entry for SOCS1

1. General information

Official gene symbolSOCS1
Entrez ID8651
Gene full namesuppressor of cytokine signaling 1
Other gene symbolsCIS1 CISH1 JAB SOCS-1 SSI-1 SSI1 TIP3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001932Regulation of protein phosphorylationISSbiological_process
GO:0004860Protein kinase inhibitor activityTASmolecular_function
GO:0005159Insulin-like growth factor receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006469Negative regulation of protein kinase activityTASbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0016023Cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0016567Protein ubiquitinationIEAbiological_process
GO:0019210Kinase inhibitor activityISSmolecular_function
GO:0019221Cytokine-mediated signaling pathwayISS TASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0040008Regulation of growthIEAbiological_process
GO:0042518Negative regulation of tyrosine phosphorylation of Stat3 proteinISSbiological_process
GO:0043086Negative regulation of catalytic activityISS TASbiological_process
GO:0045444Fat cell differentiationIEAbiological_process
GO:0045859Regulation of protein kinase activityTASbiological_process
GO:0046426Negative regulation of JAK-STAT cascadeISS NASbiological_process
GO:0046627Negative regulation of insulin receptor signaling pathwayISSbiological_process
GO:0050790Regulation of catalytic activityISS TASbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060334Regulation of interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0060338Regulation of type I interferon-mediated signaling pathwayTASbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTASbiological_process
GO:0071230Cellular response to amino acid stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.54990283420.14080214660.99999024730.7213027053

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0704934948
GSE13712_SHEARUp0.1688920249
GSE13712_STATICUp0.0940412482
GSE19018Down-0.0533784159
GSE19899_A1Down-0.4877137530
GSE19899_A2Down-0.1317929987
PubMed_21979375_A1Down-0.1379260215
PubMed_21979375_A2Down-0.2623606042
GSE35957Up0.1151313090
GSE36640Down-1.6737907533
GSE54402Down-0.9431881055
GSE9593Down-0.0389723637
GSE43922Down-0.0573065571
GSE24585Up0.3080825772
GSE37065Down-0.0394877761
GSE28863_A1Up0.1683762343
GSE28863_A2Up0.1847760587
GSE28863_A3Up0.5584557621
GSE28863_A4Up0.1033612387
GSE48662Down-0.1805113358

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT000456qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20354188
hsa-miR-155-5pMIMAT0000646MIRT000456Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22387553
hsa-miR-155-5pMIMAT0000646MIRT000456Luciferase reporter assayFunctional MTI22771905
hsa-miR-155-5pMIMAT0000646MIRT000456ProteomicsFunctional MTI (Weak)18668040
hsa-let-7i-5pMIMAT0000415MIRT006373Luciferase reporter assayFunctional MTI21742974
hsa-miR-30b-5pMIMAT0000420MIRT006325Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22387553
hsa-miR-19b-3pMIMAT0000074MIRT004336Luciferase reporter assay//Western blotFunctional MTI18728182
hsa-miR-19a-3pMIMAT0000073MIRT004337Luciferase reporter assay//Western blotFunctional MTI18728182
hsa-miR-122-5pMIMAT0000421MIRT007084GFP reporter assayFunctional MTI23348614
hsa-miR-30c-5pMIMAT0000244MIRT007132qRT-PCRFunctional MTI (Weak)23418453
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-155-5pMIMAT0000646NAhsa-miR-155{Immunofluorescence}{overexpression}20354188
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.