HCSGD entry for NUMB
1. General information
| Official gene symbol | NUMB |
|---|---|
| Entrez ID | 8650 |
| Gene full name | numb homolog (Drosophila) |
| Other gene symbols | C14orf41 S171 c14_5527 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005769 | Early endosome | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0007409 | Axonogenesis | IEA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008013 | Beta-catenin binding | IEA | molecular_function |
| GO:0016323 | Basolateral plasma membrane | IEA | cellular_component |
| GO:0019897 | Extrinsic component of plasma membrane | IEA | cellular_component |
| GO:0021670 | Lateral ventricle development | IEA ISS | biological_process |
| GO:0021849 | Neuroblast division in subventricular zone | IEA ISS | biological_process |
| GO:0030862 | Positive regulation of polarized epithelial cell differentiation | IEA | biological_process |
| GO:0034332 | Adherens junction organization | IEA | biological_process |
| GO:0045177 | Apical part of cell | IEA | cellular_component |
| GO:0045294 | Alpha-catenin binding | IEA | molecular_function |
| GO:0045296 | Cadherin binding | IEA | molecular_function |
| GO:0045746 | Negative regulation of Notch signaling pathway | IEA | biological_process |
| GO:0050769 | Positive regulation of neurogenesis | IEA ISS | biological_process |
| GO:0060487 | Lung epithelial cell differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0661681091 | 0.9379295392 | 0.5543000637 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1131421159 |
| GSE13712_SHEAR | Up | 0.7647292085 |
| GSE13712_STATIC | Up | 0.3826211796 |
| GSE19018 | Down | -0.2320404265 |
| GSE19899_A1 | Up | 0.3047699600 |
| GSE19899_A2 | Down | -0.1657967047 |
| PubMed_21979375_A1 | Up | 1.2960145116 |
| PubMed_21979375_A2 | Up | 0.1967529181 |
| GSE35957 | Down | -0.4096592727 |
| GSE36640 | Up | 0.0714446185 |
| GSE54402 | Up | 0.2592103792 |
| GSE9593 | Down | -0.1571181498 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.1569601850 |
| GSE28863_A2 | Up | 0.2570018580 |
| GSE28863_A3 | Up | 0.1147424680 |
| GSE28863_A4 | Up | 0.0601455587 |
| GSE48662 | Up | 0.1007380469 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-31-5p | MIMAT0000089 | MIRT004970 | Luciferase reporter assay//qRT-PCR | Non-Functional MTI | 19524507 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT019211 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-375 | MIMAT0000728 | MIRT020047 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT020360 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027189 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
