HCSGD entry for CDK13
1. General information
| Official gene symbol | CDK13 |
|---|---|
| Entrez ID | 8621 |
| Gene full name | cyclin-dependent kinase 13 |
| Other gene symbols | CDC2L CDC2L5 CHED hCDK13 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000380 | Alternative mRNA splicing, via spliceosome | ISS TAS | biological_process |
| GO:0002945 | Cyclin K-CDK13 complex | IPI | cellular_component |
| GO:0004672 | Protein kinase activity | TAS | molecular_function |
| GO:0004693 | Cyclin-dependent protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0007088 | Regulation of mitosis | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | TAS | biological_process |
| GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity | IDA | molecular_function |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016607 | Nuclear speck | IDA | cellular_component |
| GO:0019908 | Nuclear cyclin-dependent protein kinase holoenzyme complex | ISS | cellular_component |
| GO:0030097 | Hemopoiesis | IMP | biological_process |
| GO:0030332 | Cyclin binding | IPI | molecular_function |
| GO:0070816 | Phosphorylation of RNA polymerase II C-terminal domain | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3587360397 | 0.8427861441 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1650604250 |
| GSE13712_SHEAR | Up | 0.1196972595 |
| GSE13712_STATIC | Down | -0.0877319335 |
| GSE19018 | Up | 0.0423659347 |
| GSE19899_A1 | Down | -0.0053846838 |
| GSE19899_A2 | Up | 0.1267686107 |
| PubMed_21979375_A1 | Up | 0.3885561130 |
| PubMed_21979375_A2 | Down | -0.0340176441 |
| GSE35957 | Up | 0.1434019797 |
| GSE36640 | Down | -0.1391279870 |
| GSE54402 | Up | 0.0311451682 |
| GSE9593 | Down | -0.0781992462 |
| GSE43922 | Up | 0.0585595486 |
| GSE24585 | Up | 0.1255312156 |
| GSE37065 | Up | 0.0691193627 |
| GSE28863_A1 | Up | 0.4780906413 |
| GSE28863_A2 | Up | 0.4457491055 |
| GSE28863_A3 | Down | -0.2973160927 |
| GSE28863_A4 | Down | -0.2448748801 |
| GSE48662 | Up | 0.4785382625 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-133b | MIMAT0000770 | MIRT007125 | Luciferase reporter assay | Functional MTI | 23451058 |
| hsa-miR-29b-2-5p | MIMAT0004515 | MIRT038713 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
