HCSGD entry for PPAP2A
1. General information
| Official gene symbol | PPAP2A |
|---|---|
| Entrez ID | 8611 |
| Gene full name | phosphatidic acid phosphatase type 2A |
| Other gene symbols | LLP1a LPP1 PAP-2a PAP2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | NAS | cellular_component |
| GO:0006470 | Protein dephosphorylation | IEA | biological_process |
| GO:0006629 | Lipid metabolic process | NAS | biological_process |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0007205 | Protein kinase C-activating G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0008195 | Phosphatidate phosphatase activity | IDA NAS | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | NAS | biological_process |
| GO:0008354 | Germ cell migration | TAS | biological_process |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0019216 | Regulation of lipid metabolic process | NAS | biological_process |
| GO:0030148 | Sphingolipid biosynthetic process | TAS | biological_process |
| GO:0030518 | Intracellular steroid hormone receptor signaling pathway | TAS | biological_process |
| GO:0030521 | Androgen receptor signaling pathway | NAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046839 | Phospholipid dephosphorylation | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5825637856 | 0.0740938642 | 0.9999902473 | 0.5133520927 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1987476343 |
| GSE13712_SHEAR | Up | 0.0084360476 |
| GSE13712_STATIC | Down | -0.0074321059 |
| GSE19018 | Down | -0.5146515177 |
| GSE19899_A1 | Down | -0.3753625958 |
| GSE19899_A2 | Down | -0.3813885194 |
| PubMed_21979375_A1 | Up | 0.3294508820 |
| PubMed_21979375_A2 | Down | -0.4035968804 |
| GSE35957 | Down | -0.0023504723 |
| GSE36640 | Up | 0.6103820424 |
| GSE54402 | Down | -0.4178605108 |
| GSE9593 | Down | -0.2361002455 |
| GSE43922 | Down | -0.2771915588 |
| GSE24585 | Up | 0.3514554166 |
| GSE37065 | Up | 0.1551811073 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0350417811 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-9-5p | MIMAT0000441 | MIRT021340 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028817 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030669 | Microarray | Functional MTI (Weak) | 18591254 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
