HCSGD entry for RUNX1

1. General information

Official gene symbolRUNX1
Entrez ID861
Gene full namerunt-related transcription factor 1
Other gene symbolsAML1 AML1-EVI-1 AMLCR1 CBFA2 EVI-1 PEBP2aB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000975Regulatory region DNA bindingIDAmolecular_function
GO:0001501Skeletal system developmentIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0002318Myeloid progenitor cell differentiationIEAbiological_process
GO:0003677DNA bindingIDA IEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0005509Calcium ion bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005604Basement membraneIEAcellular_component
GO:0005634NucleusIDA IEA TAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007417Central nervous system developmentIEAbiological_process
GO:0008134Transcription factor bindingIDAmolecular_function
GO:0009966Regulation of signal transductionIEAbiological_process
GO:0030097HemopoiesisIDA TASbiological_process
GO:0030099Myeloid cell differentiationIDAbiological_process
GO:0030853Negative regulation of granulocyte differentiationIMPbiological_process
GO:0030854Positive regulation of granulocyte differentiationIMPbiological_process
GO:0031069Hair follicle morphogenesisIEAbiological_process
GO:0035162Embryonic hemopoiesisIEAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0045766Positive regulation of angiogenesisISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046982Protein heterodimerization activityIDAmolecular_function
GO:0048266Behavioral response to painIEAbiological_process
GO:0048935Peripheral nervous system neuron developmentTASbiological_process
GO:0060216Definitive hemopoiesisIEAbiological_process
GO:0070491Repressing transcription factor bindingIEAmolecular_function
GO:0071336Regulation of hair follicle cell proliferationIEAbiological_process
GO:0071425Hematopoietic stem cell proliferationTASbiological_process
GO:2000872Positive regulation of progesterone secretionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04705647200.99810739710.48026444361.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.1585503477
GSE28863_A2Up0.5329982270
GSE28863_A3Up0.2158241805
GSE28863_A4Down-0.0466759569
GSE48662Up0.3534303752

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-17-5pMIMAT0000070MIRT003741Luciferase reporter assay//Reporter assay//qRT-PCR//Western blotFunctional MTI17589498
hsa-miR-20a-5pMIMAT0000075MIRT003742Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI17589498
hsa-miR-106a-5pMIMAT0000103MIRT003743Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI17589498
hsa-miR-423-5pMIMAT0004748MIRT038069CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-106a-5pMIMAT00001031hsa-miR-106a{Western blot}{Western blot}{overexpression by mature miRNA transfection}{underexpression by 2'-O-Me antisense miRNA oligonucleotides}17589498
hsa-miR-27a-3pMIMAT0000084NAhsa-miR-27a{Western blot}{overexpression by miRNA precursor transfection}19114653
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26002684We identified a subnetwork of transcription factors, including RUNX1, IRF8, PU
12091906The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia
12091906This translocation creates a fusion protein consisting of the acute myeloid leukemia-1 transcription factor and the eight-twenty-one corepressor (AML1 ETO), which represses transcription through AML1 (RUNX1) DNA binding sites and immortalizes hematopoietic progenitor cells
12091906We have identified the p14(ARF) tumor suppressor, a mediator of the p53 oncogene checkpoint, as a direct transcriptional target of AML1 ETO
12091906AML1 ETO repressed the p14(ARF) promoter and reduced endogenous levels of p14(ARF) expression in multiple cell types
12091906In contrast, AML1 stimulated p14(ARF) expression and induced phenotypes consistent with cellular senescence
12091906Chromatin immunoprecipitation assays demonstrated that AML1 ETO was specifically bound to the p14(ARF) promoter
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