HCSGD entry for RUVBL1

1. General information

Official gene symbolRUVBL1
Entrez ID8607
Gene full nameRuvB-like 1 (E. coli)
Other gene symbolsECP54 INO80H NMP238 PONTIN Pontin52 RVB1 TIH1 TIP49 TIP49A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003678DNA helicase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005815Microtubule organizing centerIEAcellular_component
GO:0006281DNA repairIEAbiological_process
GO:0006310DNA recombinationIEAbiological_process
GO:0006334Nucleosome assemblyTASbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0007067MitosisIEAbiological_process
GO:0007283SpermatogenesisTASbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016363Nuclear matrixIEAcellular_component
GO:0016887ATPase activityIDAmolecular_function
GO:0031011Ino80 complexIDAcellular_component
GO:0032508DNA duplex unwindingIDAbiological_process
GO:0034080CENP-A containing nucleosome assembly at centromereTASbiological_process
GO:0035267NuA4 histone acetyltransferase complexIDAcellular_component
GO:0040008Regulation of growthIEAbiological_process
GO:0043141ATP-dependent 5'-3' DNA helicase activityIEAmolecular_function
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0043234Protein complexIEAcellular_component
GO:0043967Histone H4 acetylationIDAbiological_process
GO:0043968Histone H2A acetylationIDAbiological_process
GO:0071339MLL1 complexIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95163293950.01305375940.99999024730.2253036066

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3399644706
GSE13712_SHEARDown-0.0281976877
GSE13712_STATICUp0.1573626162
GSE19018Down-0.3077922624
GSE19899_A1Down-0.5682751231
GSE19899_A2Down-0.0686863093
PubMed_21979375_A1Down-0.4752548326
PubMed_21979375_A2Down-1.2871826166
GSE35957Down-1.1472784647
GSE36640Down-0.8835848663
GSE54402Up0.1583742162
GSE9593Down-0.5056138389
GSE43922Down-0.0136954466
GSE24585Down-0.8394765166
GSE37065Down-0.2486107638
GSE28863_A1Down-0.0940974369
GSE28863_A2Up0.0482861037
GSE28863_A3Up0.2144530695
GSE28863_A4Down-0.0275655213
GSE48662Down-0.3484821674

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030130MicroarrayFunctional MTI (Weak)19088304
hsa-miR-193b-3pMIMAT0002819MIRT041567CLASHFunctional MTI (Weak)23622248
hsa-miR-197-3pMIMAT0000227MIRT048128CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18410720Pontin and reptin are conserved AAA+ ATPases identified in chromatin-remodeling complexes
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