HCSGD entry for ACTL6A
1. General information
| Official gene symbol | ACTL6A |
|---|---|
| Entrez ID | 86 |
| Gene full name | actin-like 6A |
| Other gene symbols | ACTL6 ARPN-BETA Arp4 BAF53A INO80K |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003407 | Neural retina development | IEP | biological_process |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0006338 | Chromatin remodeling | IC IDA IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | NAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007399 | Nervous system development | IEA | biological_process |
| GO:0016514 | SWI/SNF complex | IDA | cellular_component |
| GO:0031011 | Ino80 complex | IDA | cellular_component |
| GO:0035267 | NuA4 histone acetyltransferase complex | IDA | cellular_component |
| GO:0040008 | Regulation of growth | IEA | biological_process |
| GO:0043967 | Histone H4 acetylation | IDA | biological_process |
| GO:0043968 | Histone H2A acetylation | IDA | biological_process |
| GO:0071564 | NpBAF complex | IDA IEA ISS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9657603548 | 0.0263972038 | 0.9999902473 | 0.3113258961 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2637583659 |
| GSE13712_SHEAR | Up | 0.1277178318 |
| GSE13712_STATIC | Up | 0.1572562791 |
| GSE19018 | Down | -0.3311026934 |
| GSE19899_A1 | Up | 0.0723592976 |
| GSE19899_A2 | Down | -0.1145461680 |
| PubMed_21979375_A1 | Down | -0.1469297536 |
| PubMed_21979375_A2 | Down | -0.4605665665 |
| GSE35957 | Down | -0.5438656798 |
| GSE36640 | Down | -1.1053696631 |
| GSE54402 | Up | 0.2239926287 |
| GSE9593 | Down | -0.5732887121 |
| GSE43922 | Down | -0.1183904249 |
| GSE24585 | Down | -0.0425443835 |
| GSE37065 | Down | -0.1115295485 |
| GSE28863_A1 | Down | -0.0541913296 |
| GSE28863_A2 | Up | 0.1505691278 |
| GSE28863_A3 | Down | -0.2442267804 |
| GSE28863_A4 | Down | -0.1022643013 |
| GSE48662 | Down | -0.7663058266 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-24-3p | MIMAT0000080 | MIRT030402 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT031321 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050215 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20660729 | Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence |
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