HCSGD entry for PRKRA
1. General information
| Official gene symbol | PRKRA |
|---|---|
| Entrez ID | 8575 |
| Gene full name | protein kinase, interferon-inducible double stranded RNA dependent activator |
| Other gene symbols | DYT16 PACT RAX |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | IEA | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0008047 | Enzyme activator activity | TAS | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0009615 | Response to virus | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0030422 | Production of siRNA involved in RNA interference | IDA | biological_process |
| GO:0034599 | Cellular response to oxidative stress | IEA | biological_process |
| GO:0042473 | Outer ear morphogenesis | IEA | biological_process |
| GO:0042474 | Middle ear morphogenesis | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0048705 | Skeletal system morphogenesis | IEA | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
| GO:2001244 | Positive regulation of intrinsic apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9857491965 | 0.0306063409 | 0.9999902473 | 0.3301596311 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3207964962 |
| GSE13712_SHEAR | Down | -0.1304773463 |
| GSE13712_STATIC | Down | -0.1035177721 |
| GSE19018 | Up | 0.0939150444 |
| GSE19899_A1 | Down | -0.1227760969 |
| GSE19899_A2 | Down | -0.6159193076 |
| PubMed_21979375_A1 | Down | -0.7361891600 |
| PubMed_21979375_A2 | Down | -0.5115201031 |
| GSE35957 | Down | -0.7912715548 |
| GSE36640 | Down | -0.6772280759 |
| GSE54402 | Down | -0.1196172165 |
| GSE9593 | Down | -0.3538715273 |
| GSE43922 | Up | 0.0060925225 |
| GSE24585 | Up | 0.3445394300 |
| GSE37065 | Down | -0.0759147268 |
| GSE28863_A1 | Down | -0.0616328996 |
| GSE28863_A2 | Up | 0.0104428864 |
| GSE28863_A3 | Down | -0.1221580423 |
| GSE28863_A4 | Down | -0.2273824236 |
| GSE48662 | Down | -0.0641280779 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 21935352 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
