HCSGD entry for PDXK
1. General information
| Official gene symbol | PDXK |
|---|---|
| Entrez ID | 8566 |
| Gene full name | pyridoxal (pyridoxine, vitamin B6) kinase |
| Other gene symbols | C21orf124 C21orf97 PKH PNK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006767 | Water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0008283 | Cell proliferation | IDA | biological_process |
| GO:0008478 | Pyridoxal kinase activity | IDA IEA TAS | molecular_function |
| GO:0009443 | Pyridoxal 5'-phosphate salvage | IEA | biological_process |
| GO:0030170 | Pyridoxal phosphate binding | IDA | molecular_function |
| GO:0030955 | Potassium ion binding | IDA | molecular_function |
| GO:0031402 | Sodium ion binding | IDA | molecular_function |
| GO:0031403 | Lithium ion binding | IDA | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0042816 | Vitamin B6 metabolic process | IC TAS | biological_process |
| GO:0042823 | Pyridoxal phosphate biosynthetic process | IDA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0654132176 | 0.9344390715 | 0.5509572160 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0260592630 |
| GSE13712_SHEAR | Up | 0.2573217031 |
| GSE13712_STATIC | Up | 0.4345389099 |
| GSE19018 | Down | -0.2544942842 |
| GSE19899_A1 | Up | 0.1306639110 |
| GSE19899_A2 | Up | 0.2722053409 |
| PubMed_21979375_A1 | Up | 0.6898544279 |
| PubMed_21979375_A2 | Up | 0.2814752953 |
| GSE35957 | Down | -0.1249711463 |
| GSE36640 | Down | -0.2542419574 |
| GSE54402 | Up | 0.4969346356 |
| GSE9593 | Down | -0.0245996766 |
| GSE43922 | Up | 0.0477733637 |
| GSE24585 | Up | 0.0250076429 |
| GSE37065 | Up | 0.1339763902 |
| GSE28863_A1 | Up | 0.6185290106 |
| GSE28863_A2 | Up | 0.7124241602 |
| GSE28863_A3 | Down | -0.6581351149 |
| GSE28863_A4 | Up | 0.1731406166 |
| GSE48662 | Down | -0.0442281012 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Pyridoxine | DB00165 | NUTR00002 | APRD00204 |
| Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate | DB03909 | EXPT00416 |
| O6-(R)-ROSCOVITINE, R-2-(6-BENZYLOXY-9-ISOPROPYL-9H-PURIN-2-YLAMINO)-BUTAN-1-OL | DB04770 | - |
| (2R)-2-({6-[benzyl(methyl)amino]-9-isopropyl-9H-purin-2-yl}amino)butan-1-ol | DB04776 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016586 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030630 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030630 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-760 | MIMAT0004957 | MIRT036737 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037478 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041816 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049519 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051266 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
