HCSGD entry for PIAS1

1. General information

Official gene symbolPIAS1
Entrez ID8554
Gene full nameprotein inhibitor of activated STAT, 1
Other gene symbolsDDXBP1 GBP GU/RH-II ZMIZ3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003713Transcription coactivator activityNASmolecular_function
GO:0003714Transcription corepressor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0016605PML bodyISScellular_component
GO:0016607Nuclear speckIEAcellular_component
GO:0016925Protein sumoylationIEA ISSbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019789SUMO ligase activityIDA IEAmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030521Androgen receptor signaling pathwayNASbiological_process
GO:0031625Ubiquitin protein ligase bindingIEAmolecular_function
GO:0032436Positive regulation of proteasomal ubiquitin-dependent protein catabolic processISSbiological_process
GO:0033235Positive regulation of protein sumoylationIDAbiological_process
GO:0042127Regulation of cell proliferationISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedNASbiological_process
GO:0050681Androgen receptor bindingNASmolecular_function
GO:0051152Positive regulation of smooth muscle cell differentiationIEAbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060334Regulation of interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0065004Protein-DNA complex assemblyIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.71121509440.40460532270.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1806604063
GSE13712_SHEARDown-0.3297437494
GSE13712_STATICDown-0.0431027169
GSE19018Up0.3184967632
GSE19899_A1Down-0.1033531663
GSE19899_A2Down-0.3059137362
PubMed_21979375_A1Up0.0467931502
PubMed_21979375_A2Down-0.1587441503
GSE35957Up0.3633070480
GSE36640Down-0.2403794809
GSE54402Down-0.2767306970
GSE9593Up0.0275291143
GSE43922Down-0.1396623543
GSE24585Up0.2793401321
GSE37065Up0.1792368077
GSE28863_A1Up0.0042226810
GSE28863_A2Down-0.0259601685
GSE28863_A3Down-0.2647397060
GSE28863_A4Up0.0634280984
GSE48662Up0.2082565646

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-424-5pMIMAT0001341MIRT003227Luciferase reporter assayNon-Functional MTI20065103
hsa-miR-124-3pMIMAT0000422MIRT022246Proteomics;MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.