HCSGD entry for LGR5
1. General information
| Official gene symbol | LGR5 |
|---|---|
| Entrez ID | 8549 |
| Gene full name | leucine-rich repeat containing G protein-coupled receptor 5 |
| Other gene symbols | FEX GPR49 GPR67 GRP49 HG38 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004888 | Transmembrane signaling receptor activity | IDA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016500 | Protein-hormone receptor activity | IEA | molecular_function |
| GO:0032588 | Trans-Golgi network membrane | IDA | cellular_component |
| GO:0048839 | Inner ear development | IEA | biological_process |
| GO:0090263 | Positive regulation of canonical Wnt signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0769123779 | 0.0249118802 | 0.5860199363 | 0.3045543892 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3456590502 |
| GSE13712_SHEAR | Down | -0.2208299710 |
| GSE13712_STATIC | Up | 0.0764295822 |
| GSE19018 | Up | 0.1943454937 |
| GSE19899_A1 | Up | 0.2617388125 |
| GSE19899_A2 | Down | -0.0509174722 |
| PubMed_21979375_A1 | Up | 0.1337587916 |
| PubMed_21979375_A2 | Down | -0.0764562599 |
| GSE35957 | Up | 0.4720063883 |
| GSE36640 | Up | 0.2151849174 |
| GSE54402 | Down | -0.0400085988 |
| GSE9593 | Down | -0.0046994468 |
| GSE43922 | Up | 0.0087191115 |
| GSE24585 | Down | -2.5437511291 |
| GSE37065 | Down | -0.1802671078 |
| GSE28863_A1 | Down | -3.0952687601 |
| GSE28863_A2 | Up | 0.8928999630 |
| GSE28863_A3 | Up | 0.1440780678 |
| GSE28863_A4 | Up | 0.8377411543 |
| GSE48662 | Down | -0.0398777923 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023026 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
