HCSGD entry for API5
1. General information
| Official gene symbol | API5 |
|---|---|
| Entrez ID | 8539 |
| Gene full name | apoptosis inhibitor 5 |
| Other gene symbols | AAC-11 AAC11 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005681 | Spliceosomal complex | ISS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | NAS | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0017134 | Fibroblast growth factor binding | IPI | molecular_function |
| GO:0043066 | Negative regulation of apoptotic process | IMP ISS NAS | biological_process |
| GO:2000270 | Negative regulation of fibroblast apoptotic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9630695452 | 0.0419487216 | 0.9999902473 | 0.3852596234 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0856863899 |
| GSE13712_SHEAR | Up | 0.1005000659 |
| GSE13712_STATIC | Down | -0.1860601728 |
| GSE19018 | Down | -0.2004292378 |
| GSE19899_A1 | Down | -0.1488089191 |
| GSE19899_A2 | Down | -0.5248368158 |
| PubMed_21979375_A1 | Down | -0.3161770324 |
| PubMed_21979375_A2 | Down | -0.3831146243 |
| GSE35957 | Up | 0.0566930946 |
| GSE36640 | Down | -0.9646296499 |
| GSE54402 | Down | -0.0445108495 |
| GSE9593 | Down | -0.2882814219 |
| GSE43922 | Down | -0.0933124969 |
| GSE24585 | Down | -0.2913317328 |
| GSE37065 | Up | 0.1036779255 |
| GSE28863_A1 | Up | 0.1292894608 |
| GSE28863_A2 | Up | 0.3668737033 |
| GSE28863_A3 | Down | -0.4692884639 |
| GSE28863_A4 | Up | 0.0230503950 |
| GSE48662 | Down | -0.8297571104 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-224-5p | MIMAT0000281 | MIRT003987 | Western blot//Luciferase reporter assay//qRT-PCR | Functional MTI | 18319255 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT025015 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-224-5p | MIMAT0000281 | 1 | hsa-miR-224 | 18319255 | |||
| hsa-miR-224-5p | MIMAT0000281 | 3 | hsa-miR-224 | 18319255 | |||
| hsa-miR-224-5p | MIMAT0000281 | 2 | hsa-miR-224 | 18319255 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
