HCSGD entry for TRIM5
1. General information
| Official gene symbol | TRIM5 |
|---|---|
| Entrez ID | 85363 |
| Gene full name | tripartite motif containing 5 |
| Other gene symbols | RNF88 TRIM5alpha |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000932 | Cytoplasmic mRNA processing body | IDA | cellular_component |
| GO:0002218 | Activation of innate immune response | IDA | biological_process |
| GO:0002221 | Pattern recognition receptor signaling pathway | IDA | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0007165 | Signal transduction | IDA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008329 | Signaling pattern recognition receptor activity | IDA | molecular_function |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0031664 | Regulation of lipopolysaccharide-mediated signaling pathway | IMP | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IMP | biological_process |
| GO:0043410 | Positive regulation of MAPK cascade | IMP | biological_process |
| GO:0045087 | Innate immune response | IEA | biological_process |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | IMP | biological_process |
| GO:0051607 | Defense response to virus | TAS | biological_process |
| GO:0070206 | Protein trimerization | IDA | biological_process |
| GO:0070534 | Protein K63-linked ubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6294849892 | 0.0141159492 | 0.9999902473 | 0.2336706767 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0177366254 |
| GSE13712_SHEAR | Up | 0.3125821151 |
| GSE13712_STATIC | Up | 0.3697008260 |
| GSE19018 | Up | 0.1604902776 |
| GSE19899_A1 | Down | -0.3733616387 |
| GSE19899_A2 | Down | -0.5839745082 |
| PubMed_21979375_A1 | Down | -1.5149319505 |
| PubMed_21979375_A2 | Down | -0.6780007416 |
| GSE35957 | Down | -0.7013579671 |
| GSE36640 | Down | -0.3772237054 |
| GSE54402 | Down | -1.0238132748 |
| GSE9593 | Down | -0.5269515097 |
| GSE43922 | Down | -1.0238603071 |
| GSE24585 | Up | 0.8141407233 |
| GSE37065 | Up | 0.7148392675 |
| GSE28863_A1 | Up | 0.1423631068 |
| GSE28863_A2 | Down | -0.0579190129 |
| GSE28863_A3 | Down | -0.4851061350 |
| GSE28863_A4 | Up | 0.1343333314 |
| GSE48662 | Down | -0.2135005467 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7a-5p | MIMAT0000062 | MIRT052397 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
