HCSGD entry for CBX4
1. General information
| Official gene symbol | CBX4 |
|---|---|
| Entrez ID | 8535 |
| Gene full name | chromobox homolog 4 |
| Other gene symbols | NBP16 PC2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0003727 | Single-stranded RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0016874 | Ligase activity | IEA | molecular_function |
| GO:0016925 | Protein sumoylation | IEA | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0031519 | PcG protein complex | IDA | cellular_component |
| GO:0032183 | SUMO binding | IDA | molecular_function |
| GO:0035064 | Methylated histone residue binding | IEA | molecular_function |
| GO:0035102 | PRC1 complex | IDA | cellular_component |
| GO:0043066 | Negative regulation of apoptotic process | TAS | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | IEA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0051219 | Phosphoprotein binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0387388435 | 0.9674713309 | 0.4442262402 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1448234066 |
| GSE13712_SHEAR | Up | 0.1863662884 |
| GSE13712_STATIC | Up | 0.1629830675 |
| GSE19018 | Up | 0.2604023467 |
| GSE19899_A1 | Down | -0.0112717020 |
| GSE19899_A2 | Up | 0.3838783138 |
| PubMed_21979375_A1 | Up | 0.1825589537 |
| PubMed_21979375_A2 | Up | 0.6067434388 |
| GSE35957 | Down | -0.0082417201 |
| GSE36640 | Up | 0.4269018882 |
| GSE54402 | Down | -0.1347940131 |
| GSE9593 | Up | 0.2858115080 |
| GSE43922 | Up | 0.0355706786 |
| GSE24585 | Up | 0.4507589845 |
| GSE37065 | Up | 0.2706214070 |
| GSE28863_A1 | Down | -0.0373527803 |
| GSE28863_A2 | Down | -0.0050992203 |
| GSE28863_A3 | Up | 0.3681257180 |
| GSE28863_A4 | Up | 0.1718584832 |
| GSE48662 | Up | 0.0191550819 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018685 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027349 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-328-3p | MIMAT0000752 | MIRT043804 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
