HCSGD entry for PKP4
1. General information
| Official gene symbol | PKP4 |
|---|---|
| Entrez ID | 8502 |
| Gene full name | plakophilin 4 |
| Other gene symbols | p0071 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000922 | Spindle pole | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005856 | Cytoskeleton | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005911 | Cell-cell junction | IDA | cellular_component |
| GO:0007043 | Cell-cell junction assembly | ISS | biological_process |
| GO:0007267 | Cell-cell signaling | NAS | biological_process |
| GO:0009898 | Cytoplasmic side of plasma membrane | IDA | cellular_component |
| GO:0010628 | Positive regulation of gene expression | ISS | biological_process |
| GO:0016337 | Cell-cell adhesion | IEA | biological_process |
| GO:0030057 | Desmosome | IDA | cellular_component |
| GO:0030155 | Regulation of cell adhesion | NAS | biological_process |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0032321 | Positive regulation of Rho GTPase activity | IDA IEA | biological_process |
| GO:0032467 | Positive regulation of cytokinesis | IEA IMP | biological_process |
| GO:0044291 | Cell-cell contact zone | IDA | cellular_component |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0051233 | Spindle midzone | IDA | cellular_component |
| GO:0072686 | Mitotic spindle | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9214887124 | 0.0187058356 | 0.9999902473 | 0.2683140599 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3287906131 |
| GSE13712_SHEAR | Down | -0.3716562557 |
| GSE13712_STATIC | Down | -0.5936503258 |
| GSE19018 | Up | 0.2884636251 |
| GSE19899_A1 | Down | -0.2960975376 |
| GSE19899_A2 | Down | -0.5909349782 |
| PubMed_21979375_A1 | Down | -0.9564018796 |
| PubMed_21979375_A2 | Down | -0.4205134073 |
| GSE35957 | Up | 0.3848297648 |
| GSE36640 | Down | -0.1640072479 |
| GSE54402 | Down | -0.1817531737 |
| GSE9593 | Up | 0.2600786731 |
| GSE43922 | Down | -0.4481565146 |
| GSE24585 | Up | 0.1326089611 |
| GSE37065 | Down | -0.6232641077 |
| GSE28863_A1 | Up | 0.0341145508 |
| GSE28863_A2 | Up | 0.3149040616 |
| GSE28863_A3 | Down | -0.4851795019 |
| GSE28863_A4 | Down | -0.1558066415 |
| GSE48662 | Down | -0.0820022425 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024827 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026600 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
