HCSGD entry for UBASH3B
1. General information
| Official gene symbol | UBASH3B |
|---|---|
| Entrez ID | 84959 |
| Gene full name | ubiquitin associated and SH3 domain containing B |
| Other gene symbols | STS-1 STS1 TULA-2 p70 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004725 | Protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006469 | Negative regulation of protein kinase activity | IEA | biological_process |
| GO:0051279 | Regulation of release of sequestered calcium ion into cytosol | IEA | biological_process |
| GO:0090331 | Negative regulation of platelet aggregation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9278617872 | 0.0406200904 | 0.9999902473 | 0.3802230387 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1140533301 |
| GSE13712_SHEAR | Down | -0.4150444105 |
| GSE13712_STATIC | Down | -0.4107955037 |
| GSE19018 | Down | -0.5541181036 |
| GSE19899_A1 | Up | 0.1403191466 |
| GSE19899_A2 | Down | -0.1842655045 |
| PubMed_21979375_A1 | Down | -0.8358100123 |
| PubMed_21979375_A2 | Down | -0.0925404670 |
| GSE35957 | Up | 0.0167557779 |
| GSE36640 | Down | -0.0754117300 |
| GSE54402 | Down | -0.1479940571 |
| GSE9593 | Up | 0.3546595543 |
| GSE43922 | Up | 0.0625742607 |
| GSE24585 | Down | -0.2223474626 |
| GSE37065 | Down | -0.2391580810 |
| GSE28863_A1 | Down | -0.4613898029 |
| GSE28863_A2 | Up | 0.2416780206 |
| GSE28863_A3 | Down | -0.2020274448 |
| GSE28863_A4 | Up | 0.1358709865 |
| GSE48662 | Down | -0.4116072267 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024758 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026942 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27016071 | Consistent with these results, both total and mitochondrial-specific ROS increased in cells undergoing replicative senescence along with ribosomal p70 phosphorylation |
| 25119968 | To verify whether truncated nibrin (p70), causing Nijmegen Breakage Syndrome (NBS), is involved in DDR and cell fate upon DNA damage, we used two (S4 and S3R) spontaneously immortalized T cell lines from NBS patients, with the founding mutation and a control cell line (L5) |
| 25119968 | S4 and S3R cells have the same level of p70 nibrin, however p70 from S4 cells was able to form more complexes with ATM and BRCA1 |
| 25119968 | Our results indicate that a substantially reduced level of nibrin or its truncated p70 form is sufficient to induce DNA-damage dependent senescence in VSMCs and S4 cells, respectively |
| 24713059 | These analyses suggest a role for Akt, nuclear factor-kappaB (NF-kappaB), heat shock protein 90 (HSP90), p70/p80 autoantigen, 14-3-3 proteins, and dynein in telomere functions |
| 24036549 | Similarly, an inhibitor of p70 S6 kinase (PF-4708671) partially inhibited phosphorylation of S6 and preserved RP, while only marginally prevented cyclin D1 induction |
| 18498745 | In this report, we identified insulin receptor substrate 1 (IRS-1), a critical mediator of the insulin/insulin-like growth factor 1 signaling, as a proteolytic target of the CUL7 E3 ligase in a manner that depends on mammalian target of rapamycin and the p70 S6 kinase activities |
| 9325154 | Our results showed that replicative senescence significantly decreased the nuclear level of both p70 and p86 components of Ku autoantigen |
| 9325154 | SV-40 immortalization and cellular quiescence did not affect the level of the p86 component but slightly increased that of p70 |
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