HCSGD entry for SPPL2A
1. General information
| Official gene symbol | SPPL2A |
|---|---|
| Entrez ID | 84888 |
| Gene full name | signal peptide peptidase like 2A |
| Other gene symbols | IMP3 PSL2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004190 | Aspartic-type endopeptidase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005765 | Lysosomal membrane | IDA IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006509 | Membrane protein ectodomain proteolysis | IDA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030660 | Golgi-associated vesicle membrane | IDA | cellular_component |
| GO:0031293 | Membrane protein intracellular domain proteolysis | IDA IMP | biological_process |
| GO:0031902 | Late endosome membrane | IEA | cellular_component |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0050776 | Regulation of immune response | IMP | biological_process |
| GO:0071458 | Integral component of cytoplasmic side of endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0071556 | Integral component of lumenal side of endoplasmic reticulum membrane | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1405720641 | 0.4496456442 | 0.7528063072 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3531040671 |
| GSE13712_SHEAR | Up | 0.3139850820 |
| GSE13712_STATIC | Down | -0.1592926825 |
| GSE19018 | Up | 0.3712991736 |
| GSE19899_A1 | Down | -0.6381583524 |
| GSE19899_A2 | Up | 0.0891077405 |
| PubMed_21979375_A1 | Down | -0.5125898625 |
| PubMed_21979375_A2 | Down | -0.3971286605 |
| GSE35957 | Up | 0.3540144106 |
| GSE36640 | Up | 0.1989699009 |
| GSE54402 | Down | -0.2188406418 |
| GSE9593 | Up | 0.2671864367 |
| GSE43922 | Up | 0.0525098398 |
| GSE24585 | Up | 0.2728333647 |
| GSE37065 | Up | 0.3675675345 |
| GSE28863_A1 | Up | 0.3599662252 |
| GSE28863_A2 | Up | 0.2202350341 |
| GSE28863_A3 | Down | -0.3191882203 |
| GSE28863_A4 | Up | 0.3248722050 |
| GSE48662 | Up | 0.0262593902 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
