HCSGD entry for GEMIN2
1. General information
| Official gene symbol | GEMIN2 |
|---|---|
| Entrez ID | 8487 |
| Gene full name | gem (nuclear organelle) associated protein 2 |
| Other gene symbols | SIP1 SIP1-delta |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000245 | Spliceosomal complex assembly | IEA | biological_process |
| GO:0000375 | RNA splicing, via transesterification reactions | TAS | biological_process |
| GO:0000387 | Spliceosomal snRNP assembly | IDA IEA TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005681 | Spliceosomal complex | IEA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006397 | MRNA processing | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0032797 | SMN complex | IDA | cellular_component |
| GO:0034660 | NcRNA metabolic process | TAS | biological_process |
| GO:0034719 | SMN-Sm protein complex | IDA | cellular_component |
| GO:0097504 | Gemini of coiled bodies | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9979151476 | 0.0055243342 | 0.9999902473 | 0.1505238095 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3812202100 |
| GSE13712_SHEAR | Down | -0.1732501524 |
| GSE13712_STATIC | Up | 0.0964166610 |
| GSE19018 | Down | -0.3118953330 |
| GSE19899_A1 | Down | -0.1156270564 |
| GSE19899_A2 | Down | -1.2083612392 |
| PubMed_21979375_A1 | Down | -0.2902186841 |
| PubMed_21979375_A2 | Down | -1.0180707273 |
| GSE35957 | Down | -0.6490882393 |
| GSE36640 | Down | -1.4104969119 |
| GSE54402 | Down | -0.5903982731 |
| GSE9593 | Down | -0.9110152547 |
| GSE43922 | Up | 0.0260515678 |
| GSE24585 | Down | -0.2306829260 |
| GSE37065 | Down | -0.0200840461 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0932123771 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-200c-3p | MIMAT0000617 | MIRT000725 | Reporter assay | Functional MTI | 18381893 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT002481 | Reporter assay | Functional MTI | 18381893 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26378039 | SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells |
| 26378039 | Here, we report that the Smad-interacting protein-1 (SIP1) is transcriptionally activated and functions critically in the GADD45G-induced tumor cell senescence |
| 26378039 | The essential role of SIP1 in GADD45G activities is further validated in the model of the proteasome inhibitor MG132-induced cell senescence |
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