HCSGD entry for CAT
1. General information
| Official gene symbol | CAT |
|---|---|
| Entrez ID | 847 |
| Gene full name | catalase |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000302 | Response to reactive oxygen species | IMP | biological_process |
| GO:0001657 | Ureteric bud development | IEA | biological_process |
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0001822 | Kidney development | IEA | biological_process |
| GO:0004046 | Aminoacylase activity | IEA | molecular_function |
| GO:0004096 | Catalase activity | IDA TAS | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005758 | Mitochondrial intermembrane space | IEA | cellular_component |
| GO:0005764 | Lysosome | IEA | cellular_component |
| GO:0005777 | Peroxisome | IDA | cellular_component |
| GO:0005778 | Peroxisomal membrane | ISS | cellular_component |
| GO:0005782 | Peroxisomal matrix | TAS | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006144 | Purine nucleobase metabolic process | TAS | biological_process |
| GO:0006195 | Purine nucleotide catabolic process | TAS | biological_process |
| GO:0006641 | Triglyceride metabolic process | IEA | biological_process |
| GO:0008203 | Cholesterol metabolic process | IEA | biological_process |
| GO:0009060 | Aerobic respiration | IEA | biological_process |
| GO:0009650 | UV protection | IMP | biological_process |
| GO:0014068 | Positive regulation of phosphatidylinositol 3-kinase signaling | IEA | biological_process |
| GO:0016209 | Antioxidant activity | IDA | molecular_function |
| GO:0016684 | Oxidoreductase activity, acting on peroxide as acceptor | ISS | molecular_function |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0020027 | Hemoglobin metabolic process | IEA | biological_process |
| GO:0020037 | Heme binding | IDA | molecular_function |
| GO:0032088 | Negative regulation of NF-kappaB transcription factor activity | IEA | biological_process |
| GO:0033197 | Response to vitamin E | IEA | biological_process |
| GO:0042697 | Menopause | IEA | biological_process |
| GO:0042744 | Hydrogen peroxide catabolic process | IDA | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050661 | NADP binding | IDA | molecular_function |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | IEA | biological_process |
| GO:0051262 | Protein tetramerization | IDA | biological_process |
| GO:0051289 | Protein homotetramerization | IDA | biological_process |
| GO:0051781 | Positive regulation of cell division | IEA | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
| GO:0055093 | Response to hyperoxia | IEA | biological_process |
| GO:0071363 | Cellular response to growth factor stimulus | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5673169143 | 0.1629553512 | 0.9999902473 | 0.7799868703 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0929419230 |
| GSE13712_SHEAR | Down | -0.6922499202 |
| GSE13712_STATIC | Down | -0.2762319505 |
| GSE19018 | Up | 0.1357575438 |
| GSE19899_A1 | Down | -0.2203400054 |
| GSE19899_A2 | Up | 0.0004153040 |
| PubMed_21979375_A1 | Down | -0.6199855175 |
| PubMed_21979375_A2 | Down | -0.3793864550 |
| GSE35957 | Down | -0.2872840226 |
| GSE36640 | Up | 0.6802856165 |
| GSE54402 | Down | -0.1011889982 |
| GSE9593 | Up | 0.0275601358 |
| GSE43922 | Down | -0.2814054978 |
| GSE24585 | Up | 0.4653173172 |
| GSE37065 | Down | -0.2059016998 |
| GSE28863_A1 | Up | 0.3291891468 |
| GSE28863_A2 | Up | 0.2163400384 |
| GSE28863_A3 | Down | -0.0985628154 |
| GSE28863_A4 | Down | -0.0147875210 |
| GSE48662 | Up | 0.2573481248 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Fomepizole | DB01213 | APRD00985 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30b-5p | MIMAT0000420 | MIRT007067 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22880027 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020866 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028614 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047237 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 59 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26696133 | The levels of some antioxidant enzymes, such as catalase, peroxiredoxin II and glutathione peroxidase I, were transiently induced by PPKO treatment |
| 25852816 | Using cultured fibroblasts with trisomy 21 (T21F), this study aimed to ascertain whether an imbalance exists in activities, mRNA, and protein expression of the antioxidant enzymes SOD1, SOD2, glutathione-peroxidase, and catalase during the cell replication process in vitro |
| 25839657 | Intracellular ROS levels were increased in hBM-MSCs; this was accompanied by a decrease in the expression of the antioxidant enzymes catalase and superoxide dismutase (SOD)1 and 2 and of phosphorylated forkhead box O1 (p-FOXO1) as well as an increase in the expression of p53 and p16, along with a reduction in differentiation potential |
| 25839657 | When the antioxidant ascorbic acid was used to eliminate excess ROS, the levels of antioxidant enzymes (catalase, SOD1 and 2, p-FOXO1, and p53) were partly restored |
| 25835220 | METHODS: We measured the expression of the deacetylase Sirtuin 1 (Sirt1) and its transcriptional target Forkhead box O3a (Foxo3a); TBARS, a well-known marker of overall oxidative stress, and catalase activity as index of antioxidation |
| 25753392 | The study examined standard quality parameters, glutathione, catalase and superoxide dismutase (SOD) activities, and indicative markers of oxidative cell damage including post-translational haemoglobin modification, malondialdehyde (MDA), and phosphatidylserine expression |
| 25703056 | We further confirmed a significant decrease in ROS accumulation accompanied by an increase in catalase in RO group |
| 25703056 | CONCLUSIONS: RO, a potent PPAR-gamma activator, counteracts senescence-like phenotypes, including long-term growth arrest, flattened morphology, degradation of ECM and SA-beta-gal-positive staining in MDFs by inhibiting the expression of MMPs and increasing the synthesis of catalase when administered to repeated UVB irradiation |
| 25655933 | Furthermore, the activation of the antioxidant enzymes catalase and SOD, downstream FoxO3a targets, was significantly decreased, thereby leading to cell cycle arrest in G1-phase by increased ROS generation and subsequently the activation of the p27(Kip1) pathway |
| 25655933 | However, FoxO3a overexpression in primary low-passage CMECs not only significantly suppressed the senescence process by increasing the activation of catalase and SOD but also markedly inhibited ROS generation and p27(Kip1) activation, although it failed to reverse cellular senescence |
| 25647436 | Balding DPCs had higher levels of catalase and total glutathione but appear to be less able to handle oxidative stress compared with occipital DPCs |
| 25647160 | Treatment of keratinocytes with resveratrol transactivated FOXO3 and increased the expression of its target genes including catalase |
| 25344604 | E2F1 attenuates FOXO3-mediated expression of MnSOD and Catalase without affecting FOXO3 protein stability, subcellular localization, or phosphorylation by Akt |
| 25238775 | This was probably related to the augmented activity of antioxidative systems, including superoxide dismutase, catalase, and reduced glutathione |
| 25196711 | Molecule activity was assessed on reactive oxygen species (ROS) production, on superoxide dismutase (SOD) and catalase activities and, finally, on inflammatory factor production IL-6, IL-8 and IL-1beta |
| 25196711 | In addition, an induction of SOD and catalase activity was clearly observed for Glc-CA |
| 25186470 | Knockdown of FOXO1 and FOXO1+3 resulted in significant reductions in levels of glutathione peroxidase 1 (GPX-1), catalase, light chain 3 (LC3), Beclin1, and sirtuin 1 (SIRT-1) proteins following treatment with tBHP |
| 25101957 | PPARgamma up-modulation counteracted the antioxidant imbalance induced by PUVA and reduced the expression of stress response genes with a synergistic increase of different components of the cell antioxidant network, such as catalase and reduced glutathione |
| 24984152 | HKa increased intracellular level of H2O2, without affecting the expression of catalase |
| 24616707 | The bulk of the ROS are neutralized by the RBC antioxidant system consisting of both non-enzymatic and enzymatic antioxidants including catalase, glutathione peroxidase and peroxiredoxin-2 |
| 24461061 | Interestingly, pyocyanin significantly inhibited cell proliferation and triggered the production of large amounts of reactive oxygen species (ROS), thereby upregulating superoxide dismutase (SOD) and catalase (CAT) |
| 24305779 | Young workers had higher reactive oxygen species levels, higher superoxide dismutase and thioredoxin reductase activities as well as lower catalase and glutathione peroxidase activities compared to old workers |
| 23988789 | We show that the phototoxic effects of peroxisomal KillerRed induce mitochondria-mediated cell death and that this process can be counteracted by targeted overexpression of a select set of antioxidant enzymes, including peroxisomal glutathione S-transferase kappa 1, superoxide dismutase 1, and mitochondrial catalase |
| 23948056 | RESULTS: In cellular ageing of HDFs, catalase and glutathione peroxidase activities were reduced, but SOD activity was heightened during pre-senescence |
| 23933099 | Interestingly, we found an increased amount of intracellular ROS in these cells, which was accompanied by elevated expression of catalase and peroxiredoxin-1 |
| 23763475 | H2 O2 increased the expression of stress defence genes, including catalase, cytochrome B alpha, lactoperoxidase and thioredoxin domain containing 2 |
| 23742046 | The alteration in regulation and synthesis of Forkhead box O3a (FoxO3a) family of transcription factors as well as major antioxidant enzymes (manganese superoxide dismutase, catalase) are also seen in aging |
| 23738955 | Young queens had lower ROS levels, lower superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities, and higher thioredoxin reductase (TR) activity compared to old queens |
| 23579096 | Amadori products promote cellular senescence activating insulin-like growth factor-1 receptor and down-regulating the antioxidant enzyme catalase |
| 23579096 | Activation of IGF-1R, after GA addition, promoted a reduction in the catalase content through the constitutive activation of Ras and erk1/2 proteins which were, in turn, responsible of the observed GA-induced senescence |
| 23579096 | In conclusion, we propose that the Amadori product, glycated albumin, promotes premature cell senescence in mesangial cells through the activation of the IGF-1 receptor and the subsequent reduction in the antioxidant enzyme catalase |
| 23494737 | We have demonstrated that overexpression of SIRT3 under high glucose conditions reduces FOXO1 acetylation, suggesting that deacetylation of FOXO1 by SIRT3 elevates the expression of the FOXO1 target genes, catalase, and manganese superoxide dismutase (MnSOD) while decreasing senescence phenotypes |
| 23494737 | The data showed that shRNA-SIRT3 accelerated senescence phenotypes and acetylation of FOXO1; the expression level of catalase and MnSOD decreased compared with the control group |
| 23430617 | PGC-1alpha disruption results in reduced expression of the longevity-related deacetylase sirtuin 1 (SIRT1) and the antioxidant catalase, and increased expression of the senescence marker p53 in aortas |
| 23430617 | Acetylation of PGC-1alpha by angiotensin II interrupts the PGC-1alpha-forkhead box O1-SIRT1 feed-forward signaling circuit leading to SIRT1 and catalase downregulation and vascular senescence |
| 23383735 | Enhanced hippocampus-dependent memory and reduced anxiety in mice over-expressing human catalase in mitochondria |
| 23383735 | In this study, we characterized behavioral and cognitive performance of 5- to 6-month-old mice over-expressing mitochondrial catalase (MCAT) |
| 23383735 | Catalase activity was elevated in MCAT mice in all brain regions examined |
| 23383735 | Catalase over-expression might be sufficient to enhance cognition and reduce measures of anxiety even in the absence of alteration in levels of OS |
| 23261989 | IGF-1 did not alter superoxide dismutase or catalase activity but markedly increased activity of glutathione peroxidase (GPX), a crucial antioxidant enzyme, via a phosphoinositide-3 kinase dependent pathway |
| 22427991 | Zinc and ZnT3/ZnT10 downregulation induces senescence by decreasing the expression of catalase |
| 22427991 | Consistently, ZnT3 and ZnT10 downregulation by siRNA increases ROS while downregulation of catalase by siRNA induces senescence |
| 22427991 | Zinc, siZnT3 and siZnT10 downregulate catalase by a post-transcriptional mechanism mediated by decreased phosphorylation of ERK1/2 |
| 22395138 | METHODS: To evaluate the neuroprotective roles of yakuchinone B (JC6) and its structural analogues (JC1-JC5), the free radical scavenging capabilities of yakuchinone B derivatives were studied in terms of cell viability, apoptosis, cells ROS content, catalase (CAT) and superoxide dismutase (SOD) activity and the intracellular lipofuscin content in SK-N-MC cells exposed to H2O2 |
| 22142804 | Effect of selenium supplementation on glutathione peroxidase and catalase activities in senescent cultured human fibroblasts |
| 22142804 | AIMS: To investigate the effect of senescence and selenium supplementation on glutathione peroxidase (cGPx) and catalase (CAT) activities, and concurrent hydrogen peroxide (H(2)O(2)) generation in subcultured human fibroblasts |
| 21515304 | Stress induced premature senescence (SIPS) in mammalian cells is an accelerated ageing response and experimentally obtained on treatment of cells with high concentrations of H(2)O(2), albeit at sub-lethal doses, because H(2)O(2) gets depleted by abundant cellular catalase |
| 20545749 | Vital cellular functions like the transcription and translation apparatus, transport systems, amino acid synthesis and degradation, respiration, ATP synthesis, glycolysis, the TCA cycle, chaperone functions and catalase are targeted by UVA irradiation |
| 20523116 | Treatment of NOX4 overexpressing cells with catalase resulted in decreased tumorigenic characteristics |
| 19616052 | The activity of intracellular antioxidant enzymes, such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT), was all significantly increased at 12h after the microgravity onset, yet decreased at 96h |
| 19285550 | Results indicate that histamine treatment (10 microM) significantly increased hydrogen peroxide levels, whereas it slightly decreased superoxide levels associated with an enhancement of superoxide dismutase and a reduction in catalase activity |
| 19285550 | Additionally, catalase treatment reversed the inhibitory effect of histamine on proliferation, and various treatments that reduce hydrogen peroxide formation increased proliferation of these cells |
| 19064796 | CD36 and catalase expression are regulated by peroxisome proliferator activated receptor-gamma agonists (eg, rosiglitazone) |
| 19064796 | The beneficial role of peroxisome proliferator activated receptor-gamma-induced catalase expression in the context of phagocytosis is also discussed |
| 21432071 | METHODS: To determine cytosolic superoxide dismutase (SOD) activities, cytosolic glutathione peroxidase (GSH-Px) activities, catalase activities, reduced glutathione (GSH) concentrations, and growth rate, MEBB treatments were performed on young and old cells |
| 21432071 | The catalase activities of the young and old cells treated with MEBB were equal to those of control cells |
| 17822396 | Restoration of peroxisomal catalase import in a model of human cellular aging |
| 17822396 | The organelle also contains catalase, which readily decomposes the hydrogen peroxide, a potentially damaging oxidant |
| 17822396 | Previous work has demonstrated that aging compromises peroxisomal protein import with catalase being particularly affected |
| 17822396 | The resultant imbalance in the relative ratio of oxidases to catalase was seen as a potential contributor to cellular oxidative stress and aging |
| 17822396 | Here we report that altering the peroxisomal targeting signal of catalase to the more effective serine-lysine-leucine (SKL) sequence results in a catalase molecule that more strongly interacts with its receptor and is more efficiently imported in both in vitro and in vivo assays |
| 17822396 | A dramatic reduction in cellular hydrogen peroxide levels accompanies this increased peroxisomal import of catalase |
| 12405449 | Antioxidants (sodium ascorbate, N-acetyl-L-cysteine, catalase) abrogated Dex-dependent cell death |
| 11595405 | Increases in the activities of superoxide dismutase and glutathione peroxidase were observed prior to the increase in 8-oxo-2'-deoxyguanosine content, while the catalase activity decreased gradually during in vitro cellular aging at late-passage |
| 11382788 | In the present study, the steady-state expression of manganese-containing superoxide dismutase, copper- and zinc-containing superoxide dismutase, catalase, and glutathione peroxidase was assessed in primary hepatocytes isolated from young and senescent rats and cultured in MATRIGEL: There was no change in steady-state superoxide dismutase protein or activity levels in cells collected from young animals and cultured for 7 days |
| 11382788 | Catalase expression was initially increased, and then it declined 30% |
| 11382788 | In contrast, superoxide dismutase expression declined 60% and catalase expression declined 50% in cells from senescent animals |
| 11294644 | Catalase did not inhibit this oxidative DNA damage, indicating no or little participation of H(2)O(2) in DNA damage |
| 10868346 | Young and old cells treated with WSP or HC were superior to the control in catalase activity with the exception of HC-treated old cells |
| 10868346 | Such increases in catalase activity and GSH concentration by WSP treatment may be related to the delay of cellular aging-dependent degeneration |
| 10724340 | Epithelial cells were sequentially isolated along the axis and the specific activities of the peroxisomal enzymes catalase and acyl-CoA oxidase were found to be significantly higher in differentiated and mature cells situated at the villus tip and stem than in the crypt |
| 10722838 | The effects of homocysteine on both senescence and telomere length are inhibited by treatment with the peroxide scavenger catalase |
| 10362024 | We also determined the activities and mRNA abundances of antioxidant defenses including superoxide dismutase, catalase, and glutathione peroxidase |
| 10362024 | Catalase activity was also elevated in senescent fibroblasts |
| 10362024 | However, no differences in catalase mRNA abundance were observed |
| 10197787 | There were no significant differences in the activities of antioxidant enzymes including superoxide dismutase, glutathione peroxidase and catalase between young and aged mice that underwent sham operation |
| 10197787 | Intestinal I/R caused a significant decrease in catalase activity only in aged mice |
| 10197787 | In conclusion, our results indicate that aged mice are more susceptible to mortality due to intestinal I/R and that an age-dependent decrease in catalase activity may contribute to the observed mortality |
| 9433911 | Suppression of intracellular hydrogen peroxide generation and catalase levels in CD8+ T-lymphocytes from HIV+ individuals |
| 9433911 | To test our hypothesis that the cell type is functionally defective in the biochemical indices related to cell proliferation, we investigated the profiles of intracellularly generated H2O2 levels with or without PMA as well as immunoreactive catalase levels using flow cytometric method |
| 9433911 | Furthermore, the immunoreactive catalase content was lower in CD8+ cells compared with CD4+ cells only in HIV+ individuals |
| 7923599 | Inherent damage, due to cellular endogenous oxidation of DNA, increased significantly upon inhibition of catalase activity in human cells with 10 mM azide |
| 1383771 | In contrast, the level of antioxidant defenses provided by activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione concentration neither uniformly declines with age nor corresponds to variations in MLSP of different mammalian species |
| 1450609 | Aerobic cells contain various amounts of the three main antioxidant enzymes: superoxide dismutase (SOD), catalase and GSH peroxidase |
| 1450609 | Amongst them, GSH peroxidase was shown to be more efficient than catalase and much more than SOD |
| 15374429 | The effects of the molecular environment on the kinetics of catalase reaction and its relevance to cell aging |
| 3013911 | To prevent the tissue injury due to reperfusion pre treatment by SOD, catalase, allopurinol are at their beginning but the first results are hopeful for skin, kidney, heart and pancreas |
| 6712629 | 2) and catalase (EC 1 |
| 7139130 | Erythrocytes from freshly drawn human blood were washed and suspended in isoosmotic phosphate-buffered saline and incubated with sodium azide to inhibit the catalase |
| 7132238 | The specific activities of glucose-6-phosphate dehydrogenase, catalase, glutathione peroxidase, glutathione reductases as well as the glutathione and selenium content were highest in the youngest cell and uniformly decreased by about 20-30% in the eldest group |
| 6893680 | Catalase activity in the tumor was also lower than in liver; this may be indicative of a lower oxidative environment at the cellular level |
| 6893680 | These enzyme activities of the liver of tumor-bearing rats were in the same range as those of normal rat liver, except that D-amino acid oxidase activity was slightly lower, and catalase activity was markedly lower and varied in a wide range |
Entries Per Page
Displaying Page of
