HCSGD entry for TRIM63
1. General information
| Official gene symbol | TRIM63 |
|---|---|
| Entrez ID | 84676 |
| Gene full name | tripartite motif containing 63, E3 ubiquitin protein ligase |
| Other gene symbols | IRF MURF1 MURF2 RNF28 SMRZ |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IEA | molecular_function |
| GO:0004871 | Signal transducer activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA NAS | cellular_component |
| GO:0005874 | Microtubule | NAS | cellular_component |
| GO:0006936 | Muscle contraction | IEA | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010468 | Regulation of gene expression | IEA | biological_process |
| GO:0014732 | Skeletal muscle atrophy | IEA | biological_process |
| GO:0014878 | Response to electrical stimulus involved in regulation of muscle adaptation | ISS | biological_process |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0031430 | M band | IEA | cellular_component |
| GO:0031432 | Titin binding | IDA | molecular_function |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
| GO:0070555 | Response to interleukin-1 | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0409211998 | 0.9660257019 | 0.4533194024 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1060870944 |
| GSE13712_SHEAR | Up | 0.3598972859 |
| GSE13712_STATIC | Down | -0.1192425447 |
| GSE19018 | Up | 0.2403829966 |
| GSE19899_A1 | Down | -0.0602468186 |
| GSE19899_A2 | Up | 0.6047476969 |
| PubMed_21979375_A1 | Up | 1.9264446662 |
| PubMed_21979375_A2 | Up | 0.4090957817 |
| GSE35957 | Up | 0.0692337704 |
| GSE36640 | Up | 0.1241557238 |
| GSE54402 | Up | 1.2858004774 |
| GSE9593 | Up | 0.5651991847 |
| GSE43922 | Up | 0.0169711480 |
| GSE24585 | Down | -0.1851479877 |
| GSE37065 | Down | -0.1033649985 |
| GSE28863_A1 | Up | 0.0323104995 |
| GSE28863_A2 | Up | 0.0964797622 |
| GSE28863_A3 | Up | 0.0862135864 |
| GSE28863_A4 | Up | 0.1018480561 |
| GSE48662 | Up | 0.0906140449 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29a-3p | MIMAT0000086 | MIRT005909 | qRT-PCR | Functional MTI (Weak) | 21169019 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017998 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
