HCSGD entry for DPY30
1. General information
| Official gene symbol | DPY30 |
|---|---|
| Entrez ID | 84661 |
| Gene full name | dpy-30 homolog (C. elegans) |
| Other gene symbols | HDPY-30 Saf19 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005802 | Trans-Golgi network | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0016197 | Endosomal transport | IMP | biological_process |
| GO:0035097 | Histone methyltransferase complex | IDA | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0048188 | Set1C/COMPASS complex | IDA | cellular_component |
| GO:0051568 | Histone H3-K4 methylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7864130010 | 0.4521984689 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0224436967 |
| GSE13712_SHEAR | Up | 0.1019017352 |
| GSE13712_STATIC | Up | 0.0126773183 |
| GSE19018 | Up | 0.4114529072 |
| GSE19899_A1 | Down | -0.0512066318 |
| GSE19899_A2 | Down | -0.2234279544 |
| PubMed_21979375_A1 | Up | 0.1027111257 |
| PubMed_21979375_A2 | Up | 0.0468559507 |
| GSE35957 | Down | -0.4078475380 |
| GSE36640 | Down | -0.3362916200 |
| GSE54402 | Up | 0.0560929100 |
| GSE9593 | Down | -0.0596926523 |
| GSE43922 | Down | -0.0846745918 |
| GSE24585 | Up | 0.1060636893 |
| GSE37065 | Down | -0.0198530223 |
| GSE28863_A1 | Down | -0.0928893791 |
| GSE28863_A2 | Up | 0.1916340312 |
| GSE28863_A3 | Down | -0.0145522164 |
| GSE28863_A4 | Down | -0.1050088566 |
| GSE48662 | Down | -0.1586110604 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023776 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23872946 | DPY30 regulates pathways in cellular senescence through ID protein expression |
| 23872946 | Here, we identify DPY30, a member of all mammalian histone H3K4 histone methyltransferases (HMTases), as a key regulator of the proliferation potential of human primary cells |
| 23872946 | Following depletion of DPY30, cells show a severe proliferation defect and display a senescent phenotype, including a flattened and enlarged morphology, elevated level of reactive oxygen species (ROS), increased SA-beta-galactosidase activity, and formation of senescence-associated heterochromatin foci (SAHFs) |
| 23872946 | While DPY30 depletion leads to a reduced level of H3K4me3-marked active chromatin, we observed a concomitant activation of CDK inhibitors, including p16INK4a, independent of H3K4me3 |
| 23872946 | ChIP experiments show that key regulators of cell-cycle progression, including ID proteins, are under direct control of DPY30 |
| 23872946 | Because ID proteins are negative regulators of the transcription factors ETS1/2, depletion of DPY30 leads to the transcriptional activation of p16INK4a by ETS1/2 and thus to a senescent-like phenotype |
| 23872946 | Ectoptic re-introduction of ID protein expression can partially rescue the senescence-like phenotype induced by DPY30 depletion |
| 23872946 | Thus, our data indicate that DPY30 controls proliferation by regulating ID proteins expression, which in turn lead to senescence bypass |
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