HCSGD entry for FOXN1

1. General information

Official gene symbolFOXN1
Entrez ID8456
Gene full nameforkhead box N1
Other gene symbolsFKHL20 RONU WHN
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIBAbiological_process
GO:0001942Hair follicle developmentIEAbiological_process
GO:0002260Lymphocyte homeostasisIEAbiological_process
GO:0003690Double-stranded DNA bindingIBAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIBAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005667Transcription factor complexIBAcellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006952Defense responseTASbiological_process
GO:0007389Pattern specification processIBAbiological_process
GO:0008134Transcription factor bindingIBAmolecular_function
GO:0008301DNA binding, bendingIBAmolecular_function
GO:0008544Epidermis developmentTASbiological_process
GO:0009790Embryo developmentIBAbiological_process
GO:0009887Organ morphogenesisTASbiological_process
GO:0030216Keratinocyte differentiationIEAbiological_process
GO:0033081Regulation of T cell differentiation in thymusIEAbiological_process
GO:0035878Nail developmentIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0048538Thymus developmentIEAbiological_process
GO:0050673Epithelial cell proliferationIEAbiological_process
GO:0051090Regulation of sequence-specific DNA binding transcription factor activityIBAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.59895019950.80034721330.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0531940810
GSE13712_SHEARUp0.0447173595
GSE13712_STATICDown-0.0324357345
GSE19018Up0.0150963442
GSE19899_A1Up0.1257460342
GSE19899_A2Up0.1142390388
PubMed_21979375_A1Down-0.0995342322
PubMed_21979375_A2Up0.0303845531
GSE35957Down-0.0349534278
GSE36640Up0.0485324347
GSE54402Up0.0612031111
GSE9593Down-0.0990279460
GSE43922Up0.1026643831
GSE24585Up0.0609109470
GSE37065Up0.0321738509
GSE28863_A1Down-0.1504548357
GSE28863_A2Down-0.1289985050
GSE28863_A3Up0.5065339859
GSE28863_A4Up0.0824031713
GSE48662Down-0.1442613492

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24263106Blockade of TEC differentiation via conditional FoxN1 gene knockout accelerated the appearance of this phenotype to early middle age, whereas intrathymic infusion of exogenous FoxN1 cDNA into aged WT mice brought only a modest reduction in the proportion of TAp63(+) TECs, but an increase in DeltaNp63(+) TECs in the partially rejuvenated thymus
24263106Thus, TAp63 levels are positively correlated with TEC senescence but inversely correlated with expression of FoxN1 and FoxN1-regulated TEC differentiation
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