HCSGD entry for CUL1
1. General information
| Official gene symbol | CUL1 |
|---|---|
| Entrez ID | 8454 |
| Gene full name | cullin 1 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006513 | Protein monoubiquitination | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | TAS | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0009887 | Organ morphogenesis | IEA | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0019005 | SCF ubiquitin ligase complex | IDA ISS | cellular_component |
| GO:0031145 | Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IDA ISS | biological_process |
| GO:0031461 | Cullin-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0031625 | Ubiquitin protein ligase binding | IEA | molecular_function |
| GO:0051437 | Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
| GO:0051439 | Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
| GO:0097193 | Intrinsic apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8092396262 | 0.2549676266 | 0.9999902473 | 0.9683986869 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1668615969 |
| GSE13712_SHEAR | Up | 0.0117834369 |
| GSE13712_STATIC | Down | -0.0111466249 |
| GSE19018 | Down | -0.1641480760 |
| GSE19899_A1 | Down | -0.1525225125 |
| GSE19899_A2 | Up | 0.0097072827 |
| PubMed_21979375_A1 | Down | -0.5499440602 |
| PubMed_21979375_A2 | Up | 0.1606741200 |
| GSE35957 | Down | -0.2255371886 |
| GSE36640 | Down | -0.4595719043 |
| GSE54402 | Up | 0.2811113132 |
| GSE9593 | Down | -0.0076047229 |
| GSE43922 | Down | -0.0193715865 |
| GSE24585 | Up | 0.1384663977 |
| GSE37065 | Up | 0.2244872945 |
| GSE28863_A1 | Up | 0.3149326592 |
| GSE28863_A2 | Up | 0.4456354624 |
| GSE28863_A3 | Down | -0.3774250682 |
| GSE28863_A4 | Down | -0.1509638715 |
| GSE48662 | Down | -0.3391865322 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT032428 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046199 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048506 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT050028 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26003431 | Immunoblotting analysis of cullin1 and p21, and SA-beta-Galactosidase staining were performed to reveal the potential molecular basis for the impaired HESC proliferation, decidualization and cellular senescence |
| 26003431 | These abnormal HESC activities upon MLN4924 exposure were accompanied with reduced cullin1 neddylation and an aberrant accumulation of p21 |
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