HCSGD entry for HOPX
1. General information
| Official gene symbol | HOPX |
|---|---|
| Entrez ID | 84525 |
| Gene full name | HOP homeobox |
| Other gene symbols | CAMEO HOD HOP LAGY NECC1 OB1 SMAP31 TOTO |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0001829 | Trophectodermal cell differentiation | IDA IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0008016 | Regulation of heart contraction | IEA | biological_process |
| GO:0016575 | Histone deacetylation | IEA | biological_process |
| GO:0043393 | Regulation of protein binding | IEA | biological_process |
| GO:0043415 | Positive regulation of skeletal muscle tissue regeneration | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045596 | Negative regulation of cell differentiation | IDA | biological_process |
| GO:0048286 | Lung alveolus development | IEA | biological_process |
| GO:0051155 | Positive regulation of striated muscle cell differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2417923293 | 0.6159753163 | 0.9288540470 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0432362038 |
| GSE13712_SHEAR | Up | 0.5380323532 |
| GSE13712_STATIC | Up | 0.3281510624 |
| GSE19018 | Down | -0.0059805420 |
| GSE19899_A1 | Up | 0.0807491666 |
| GSE19899_A2 | Down | -0.6654694998 |
| PubMed_21979375_A1 | Down | -0.1300375337 |
| PubMed_21979375_A2 | Up | 0.1841514693 |
| GSE35957 | Down | -0.0921755053 |
| GSE36640 | Up | 0.6040925973 |
| GSE54402 | Down | -0.2807951148 |
| GSE9593 | Up | 0.0366690609 |
| GSE43922 | Up | 0.0230777100 |
| GSE24585 | Down | -0.2262618629 |
| GSE37065 | Down | -0.0262112835 |
| GSE28863_A1 | Up | 0.0469026524 |
| GSE28863_A2 | Up | 0.0802773043 |
| GSE28863_A3 | Up | 0.1854010993 |
| GSE28863_A4 | Down | -0.0664547099 |
| GSE48662 | Up | 0.4340898167 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25345926 | HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer |
| 25345926 | HOPX acts as a tumour suppressor in various cancers |
| 25345926 | However, the regulation of HOPX in human lung cancer as well as the mechanism underlying its tumour-suppressive function has not yet been well elucidated |
| 25345926 | Here we investigated the epigenetic regulation and molecular mechanism by which HOPX exerts growth inhibitory effects |
| 25345926 | We found that HOPX was down-regulated in 12 out of 13 lung cancer cell lines and in 69 out of 120 primary lung tumours at mRNA and protein levels |
| 25345926 | Patients with lung adenocarcinoma (ADC) exhibited significantly more positive staining of HOPX protein compared with lung squamous cell carcinoma (SCC) (p =0 |
| 25345926 | Again in ADC, patients with higher HOPX expression had a significantly longer disease-free survival (p =0 |
| 25345926 | Methylation analysis showed that down-regulation of HOPX was associated with DNA methylation (p =0 |
| 25345926 | To analyse the function of HOPX in lung cancer cells, stable transfection with an expression vector of HOPX was performed |
| 25345926 | It turned out that HOPX inhibited tumour cell proliferation rate, migration, and invasion, and, more interestingly, forced expression of HOPX enhanced cellular senescence via activation of oncogenic Ras and the downstream MAPK pathway, which in turn led to decreased MDM2 and increased p21 |
| 25345926 | On the contrary, knockdown of HOPX by siRNA resulted in reduced Ras activity, inactivation of the MAPK pathway, and decreased p21 levels, accompanied by reduced cellular senescence |
| 25345926 | Taken together, our data suggest that down-regulation of HOPX was related to DNA methylation and that HOPX exerts tumour-suppressive activity by oncogenic Ras-induced cellular senescence in lung cancer cells |
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