HCSGD entry for NKX6-2

1. General information

Official gene symbolNKX6-2
Entrez ID84504
Gene full nameNK6 homeobox 2
Other gene symbolsGTX NKX6.2 NKX6B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000976Transcription regulatory region sequence-specific DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityNASmolecular_function
GO:0005634NucleusNAScellular_component
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0010454Negative regulation of cell fate commitmentIEAbiological_process
GO:0010455Positive regulation of cell fate commitmentIEAbiological_process
GO:0021912Regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specificationIEAbiological_process
GO:0021913Regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specificationIEAbiological_process
GO:0022010Central nervous system myelinationIEAbiological_process
GO:0031018Endocrine pancreas developmentIEAbiological_process
GO:0045686Negative regulation of glial cell differentiationIEAbiological_process
GO:0045687Positive regulation of glial cell differentiationIEAbiological_process
GO:0050885Neuromuscular process controlling balanceIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.58359264470.67301183850.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0459635437
GSE13712_SHEARDown-0.0012419304
GSE13712_STATICDown-0.0679510424
GSE19018Up0.0268365744
GSE19899_A1Up0.0968601802
GSE19899_A2Up0.0456036312
PubMed_21979375_A1Down-0.1093005368
PubMed_21979375_A2Down-0.1528681177
GSE35957Up0.0657545084
GSE36640Up0.1237176498
GSE54402Up0.0659603916
GSE9593Down-0.2631618988
GSE43922Up0.0546380055
GSE24585Up0.0330496285
GSE37065Down-0.2358899857
GSE28863_A1Down-0.1126228864
GSE28863_A2Down-0.0728090167
GSE28863_A3Up0.4820893869
GSE28863_A4Up0.2284232804
GSE48662Up0.0562233581

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.