HCSGD entry for DYRK2
1. General information
| Official gene symbol | DYRK2 |
|---|---|
| Entrez ID | 8445 |
| Gene full name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | IDA | cellular_component |
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004712 | Protein serine/threonine/tyrosine kinase activity | IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IEP | biological_process |
| GO:0007224 | Smoothened signaling pathway | IMP | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IDA | biological_process |
| GO:0030145 | Manganese ion binding | IDA | molecular_function |
| GO:0030529 | Ribonucleoprotein complex | IEA | cellular_component |
| GO:0042771 | Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | IDA | biological_process |
| GO:0043130 | Ubiquitin binding | IDA | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0045725 | Positive regulation of glycogen biosynthetic process | IDA | biological_process |
| GO:0051534 | Negative regulation of NFAT protein import into nucleus | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9249884921 | 0.0416035029 | 0.9999902473 | 0.3838225727 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3651435526 |
| GSE13712_SHEAR | Down | -0.4979812576 |
| GSE13712_STATIC | Down | -0.0948723467 |
| GSE19018 | Down | -0.7381868728 |
| GSE19899_A1 | Down | -0.2132937495 |
| GSE19899_A2 | Down | -0.1874854373 |
| PubMed_21979375_A1 | Down | -0.9705159446 |
| PubMed_21979375_A2 | Down | -0.1987574466 |
| GSE35957 | Up | 0.5059963392 |
| GSE36640 | Down | -0.8090156594 |
| GSE54402 | Up | 0.3708909369 |
| GSE9593 | Up | 0.2008788536 |
| GSE43922 | Down | -0.0566903877 |
| GSE24585 | Down | -0.1192502542 |
| GSE37065 | Down | -0.2693295691 |
| GSE28863_A1 | Up | 0.0564806971 |
| GSE28863_A2 | Up | 0.3772005428 |
| GSE28863_A3 | Down | -0.0620359118 |
| GSE28863_A4 | Up | 0.0680901932 |
| GSE48662 | Down | -0.2027168416 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027110 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027686 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028150 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028150 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041925 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043899 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048134 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048265 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051470 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
