HCSGD entry for BRSK1
1. General information
| Official gene symbol | BRSK1 |
|---|---|
| Entrez ID | 84446 |
| Gene full name | BR serine/threonine kinase 1 |
| Other gene symbols | hSAD1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA | molecular_function |
| GO:0005524 | ATP binding | IC IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005813 | Centrosome | IEA ISS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0007269 | Neurotransmitter secretion | IEA ISS | biological_process |
| GO:0007409 | Axonogenesis | IEA ISS | biological_process |
| GO:0008021 | Synaptic vesicle | IEA ISS | cellular_component |
| GO:0009411 | Response to UV | IDA | biological_process |
| GO:0010212 | Response to ionizing radiation | IDA | biological_process |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0030010 | Establishment of cell polarity | IEA ISS | biological_process |
| GO:0030054 | Cell junction | IDA | cellular_component |
| GO:0030182 | Neuron differentiation | ISS | biological_process |
| GO:0031572 | G2 DNA damage checkpoint | IDA | biological_process |
| GO:0043015 | Gamma-tubulin binding | IEA ISS | molecular_function |
| GO:0050321 | Tau-protein kinase activity | IDA IEA ISS | molecular_function |
| GO:0051298 | Centrosome duplication | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3711538581 | 0.7845476996 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0315817620 |
| GSE13712_SHEAR | Down | -0.1408052680 |
| GSE13712_STATIC | Down | -0.1956663316 |
| GSE19018 | Up | 0.1252867891 |
| GSE19899_A1 | Down | -0.1310164913 |
| GSE19899_A2 | Up | 0.1203859030 |
| PubMed_21979375_A1 | Down | -0.3584821007 |
| PubMed_21979375_A2 | Up | 0.2720624534 |
| GSE35957 | Down | -0.2335836071 |
| GSE36640 | Up | 0.5040504599 |
| GSE54402 | Up | 0.3076577223 |
| GSE9593 | Down | -0.0533924339 |
| GSE43922 | Up | 0.0760390907 |
| GSE24585 | Up | 0.2435014382 |
| GSE37065 | Down | -0.0027966153 |
| GSE28863_A1 | Down | -0.1661611210 |
| GSE28863_A2 | Down | -0.1926831933 |
| GSE28863_A3 | Up | 0.4344479953 |
| GSE28863_A4 | Up | 0.1036268052 |
| GSE48662 | Up | 0.1634547910 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-339-5p | MIMAT0000764 | MIRT042770 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
