HCSGD entry for AKT1S1
1. General information
| Official gene symbol | AKT1S1 |
|---|---|
| Entrez ID | 84335 |
| Gene full name | AKT1 substrate 1 (proline-rich) |
| Other gene symbols | Lobe PRAS40 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA ISS TAS | cellular_component |
| GO:0006469 | Negative regulation of protein kinase activity | IDA | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0031931 | TORC1 complex | IDA | cellular_component |
| GO:0032007 | Negative regulation of TOR signaling | IDA IEA | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0043523 | Regulation of neuron apoptotic process | IEA ISS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045792 | Negative regulation of cell size | IDA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | IEA TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0061234680 | 0.8972806162 | 0.2066356410 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4757454956 |
| GSE13712_SHEAR | Down | -0.0808769992 |
| GSE13712_STATIC | Down | -0.0208306026 |
| GSE19018 | Up | 0.6169120317 |
| GSE19899_A1 | Down | -0.0006394497 |
| GSE19899_A2 | Up | 1.2899612610 |
| PubMed_21979375_A1 | Up | 0.5069881999 |
| PubMed_21979375_A2 | Up | 1.3270496293 |
| GSE35957 | Up | 0.3427887851 |
| GSE36640 | Up | 0.4709024141 |
| GSE54402 | Up | 0.3831827054 |
| GSE9593 | Up | 0.6272645636 |
| GSE43922 | Up | 0.3480583738 |
| GSE24585 | Down | -0.3247829463 |
| GSE37065 | Down | -0.2678501218 |
| GSE28863_A1 | Down | -0.3941802852 |
| GSE28863_A2 | Down | -0.3751263502 |
| GSE28863_A3 | Up | 0.3537453978 |
| GSE28863_A4 | Up | 0.1532670759 |
| GSE48662 | Up | 0.7789741101 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022786 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-484 | MIMAT0002174 | MIRT041919 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045373 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25077541 | Importantly, we found that MKP7 inhibited senescence by dephosphorylating PRAS40 at Thr246 and mTOR at Ser2248, facilitating the interaction and loss of function of both molecules |
| 24704832 | Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway |
| 24704832 | The proline-rich Akt substrate of 40 kDa (PRAS40) has recently been identified as a binding partner and inhibitor of the mechanistic (formerly referred to as mammalian) target of rapamycin complex 1 (mTORC1) |
| 24704832 | Importantly, silencing of PRAS40 induces upregulation of p53 in a manner dependent on RPL11 |
| 24704832 | This effect is rescued by wild-type PRAS40, but not by the RPL11-binding-null PRAS40T246A mutant |
| 24704832 | We found that PRAS40 negatively regulates the RPL11-HDM2-p53 nucleolar stress response pathway and suppresses induction of p53-mediated cellular senescence |
| 24704832 | This work identifies nuclear PRAS40 as a dual-input signaling checkpoint that links cell growth and proliferation to inhibition of cellular senescence |
| 24704832 | These findings may help to explain the protumorigenic effect of PRAS40 and identify the PRAS40-RPL11 complex as a promising target for p53-restorative anticancer drug discovery |
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