HCSGD entry for NR0B2
1. General information
| Official gene symbol | NR0B2 |
|---|---|
| Entrez ID | 8431 |
| Gene full name | nuclear receptor subfamily 0, group B, member 2 |
| Other gene symbols | SHP SHP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0008203 | Cholesterol metabolic process | TAS | biological_process |
| GO:0009749 | Response to glucose | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0030521 | Androgen receptor signaling pathway | RCA | biological_process |
| GO:0031100 | Organ regeneration | IEA | biological_process |
| GO:0032024 | Positive regulation of insulin secretion | IEA | biological_process |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0042975 | Peroxisome proliferator activated receptor binding | IEA | molecular_function |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0043433 | Negative regulation of sequence-specific DNA binding transcription factor activity | IDA | biological_process |
| GO:0046965 | Retinoid X receptor binding | IEA | molecular_function |
| GO:0046966 | Thyroid hormone receptor binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5005235439 | 0.7465529767 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1368172666 |
| GSE13712_SHEAR | Up | 0.0835694088 |
| GSE13712_STATIC | Down | -0.0131824198 |
| GSE19018 | Up | 0.1244637380 |
| GSE19899_A1 | Up | 0.0368570038 |
| GSE19899_A2 | Up | 0.1971052818 |
| PubMed_21979375_A1 | Down | -0.0724167648 |
| PubMed_21979375_A2 | Down | -0.0333077802 |
| GSE35957 | Up | 0.0646619071 |
| GSE36640 | Up | 0.0528444664 |
| GSE54402 | Down | -0.1365159277 |
| GSE9593 | Down | -0.0131159681 |
| GSE43922 | Up | 0.0397675221 |
| GSE24585 | Up | 0.4187977978 |
| GSE37065 | Down | -0.1016208955 |
| GSE28863_A1 | Down | -0.2825049889 |
| GSE28863_A2 | Up | 0.0320149284 |
| GSE28863_A3 | Up | 0.1004933516 |
| GSE28863_A4 | Down | -0.0025398828 |
| GSE48662 | Up | 0.1247298958 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-141-3p | MIMAT0000432 | MIRT006718 | Luciferase reporter assay | Functional MTI | 22314666 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028990 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030414 | Microarray | Functional MTI (Weak) | 19748357 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
