HCSGD entry for RHBDD1
1. General information
| Official gene symbol | RHBDD1 |
|---|---|
| Entrez ID | 84236 |
| Gene full name | rhomboid domain containing 1 |
| Other gene symbols | RRP4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004175 | Endopeptidase activity | IDA | molecular_function |
| GO:0004252 | Serine-type endopeptidase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | ISS | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0010954 | Positive regulation of protein processing | IEA ISS | biological_process |
| GO:0030176 | Integral component of endoplasmic reticulum membrane | IEA ISS | cellular_component |
| GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process | IEA ISS | biological_process |
| GO:0031293 | Membrane protein intracellular domain proteolysis | IEA ISS | biological_process |
| GO:0033619 | Membrane protein proteolysis | IDA | biological_process |
| GO:0034620 | Cellular response to unfolded protein | IEA ISS | biological_process |
| GO:0034644 | Cellular response to UV | IEA ISS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IDA IEA IMP ISS | biological_process |
| GO:0043687 | Post-translational protein modification | IEA ISS | biological_process |
| GO:0044322 | Endoplasmic reticulum quality control compartment | IEA ISS | cellular_component |
| GO:0045732 | Positive regulation of protein catabolic process | IDA IMP | biological_process |
| GO:0048515 | Spermatid differentiation | IEA ISS | biological_process |
| GO:0051047 | Positive regulation of secretion | IMP | biological_process |
| GO:2000254 | Regulation of male germ cell proliferation | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0584862163 | 0.9639069374 | 0.5243241485 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1143054664 |
| GSE13712_SHEAR | Down | -0.1410895257 |
| GSE13712_STATIC | Up | 0.2223765296 |
| GSE19018 | Up | 0.3495371419 |
| GSE19899_A1 | Up | 0.1337027586 |
| GSE19899_A2 | Up | 0.3776989260 |
| PubMed_21979375_A1 | Up | 0.6241715254 |
| PubMed_21979375_A2 | Up | 0.9758543113 |
| GSE35957 | Up | 0.0984760891 |
| GSE36640 | Up | 0.7773715467 |
| GSE54402 | Down | -0.1016884984 |
| GSE9593 | Up | 0.3428318857 |
| GSE43922 | Up | 0.4156005700 |
| GSE24585 | Down | -0.1362738922 |
| GSE37065 | Up | 0.0073109854 |
| GSE28863_A1 | Up | 0.0985465024 |
| GSE28863_A2 | Up | 0.2102733105 |
| GSE28863_A3 | Down | -0.1621565895 |
| GSE28863_A4 | Down | -0.1754044150 |
| GSE48662 | Down | -0.0013456413 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-218-5p | MIMAT0000275 | MIRT024241 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028195 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
