HCSGD entry for POLR1B
1. General information
| Official gene symbol | POLR1B |
|---|---|
| Entrez ID | 84172 |
| Gene full name | polymerase (RNA) I polypeptide B, 128kDa |
| Other gene symbols | RPA135 RPA2 Rpo1-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001054 | RNA polymerase I activity | IBA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003899 | DNA-directed RNA polymerase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005736 | DNA-directed RNA polymerase I complex | IBA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006360 | Transcription from RNA polymerase I promoter | TAS | biological_process |
| GO:0006361 | Transcription initiation from RNA polymerase I promoter | TAS | biological_process |
| GO:0006362 | Transcription elongation from RNA polymerase I promoter | TAS | biological_process |
| GO:0006363 | Termination of RNA polymerase I transcription | TAS | biological_process |
| GO:0007566 | Embryo implantation | IEA | biological_process |
| GO:0009303 | RRNA transcription | IEA | biological_process |
| GO:0009790 | Embryo development | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0017126 | Nucleologenesis | IEA | biological_process |
| GO:0032549 | Ribonucleoside binding | IEA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0267462178 | 0.4565726948 | 0.3810243506 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2266557417 |
| GSE13712_SHEAR | Up | 0.2035102343 |
| GSE13712_STATIC | Up | 0.5403089601 |
| GSE19018 | Down | -0.6944738223 |
| GSE19899_A1 | Up | 0.5088268193 |
| GSE19899_A2 | Up | 1.1762443312 |
| PubMed_21979375_A1 | Up | 0.7163583668 |
| PubMed_21979375_A2 | Up | 1.1036858608 |
| GSE35957 | Up | 0.0092096020 |
| GSE36640 | Down | -0.2622577553 |
| GSE54402 | Up | 0.2021916111 |
| GSE9593 | Down | -0.4770797725 |
| GSE43922 | Up | 0.9470529820 |
| GSE24585 | Down | -0.5189062301 |
| GSE37065 | Down | -0.0794378950 |
| GSE28863_A1 | Up | 0.1242292317 |
| GSE28863_A2 | Up | 0.3652585775 |
| GSE28863_A3 | Up | 0.0528619636 |
| GSE28863_A4 | Down | -0.1820492625 |
| GSE48662 | Down | -0.1444054247 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020763 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032367 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-365a-3p | MIMAT0000710 | MIRT044045 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
