HCSGD entry for PPP1R1B
1. General information
| Official gene symbol | PPP1R1B |
|---|---|
| Entrez ID | 84152 |
| Gene full name | protein phosphatase 1, regulatory (inhibitor) subunit 1B |
| Other gene symbols | DARPP-32 DARPP32 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001975 | Response to amphetamine | IEA | biological_process |
| GO:0004860 | Protein kinase inhibitor activity | TAS | molecular_function |
| GO:0004864 | Protein phosphatase inhibitor activity | IEA TAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006469 | Negative regulation of protein kinase activity | TAS | biological_process |
| GO:0007165 | Signal transduction | IEA TAS | biological_process |
| GO:0007621 | Negative regulation of female receptivity | IEA | biological_process |
| GO:0008542 | Visual learning | IEA | biological_process |
| GO:0008599 | Protein phosphatase type 1 regulator activity | TAS | molecular_function |
| GO:0031748 | D1 dopamine receptor binding | IEA | molecular_function |
| GO:0031749 | D2 dopamine receptor binding | IEA | molecular_function |
| GO:0031750 | D3 dopamine receptor binding | IEA | molecular_function |
| GO:0031751 | D4 dopamine receptor binding | IEA | molecular_function |
| GO:0031752 | D5 dopamine receptor binding | IEA | molecular_function |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0042325 | Regulation of phosphorylation | TAS | biological_process |
| GO:0042326 | Negative regulation of phosphorylation | TAS | biological_process |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043086 | Negative regulation of catalytic activity | TAS | biological_process |
| GO:0045859 | Regulation of protein kinase activity | TAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5063903917 | 0.8686953003 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0620543958 |
| GSE13712_SHEAR | Down | -0.1580409151 |
| GSE13712_STATIC | Down | -0.1236926628 |
| GSE19018 | Down | -0.0360841256 |
| GSE19899_A1 | Up | 0.0572138229 |
| GSE19899_A2 | Up | 0.1933417087 |
| PubMed_21979375_A1 | Up | 0.0162084181 |
| PubMed_21979375_A2 | Up | 0.1180275141 |
| GSE35957 | Up | 0.0851476600 |
| GSE36640 | Down | -0.0620257030 |
| GSE54402 | Up | 0.0080404592 |
| GSE9593 | Up | 0.0154296466 |
| GSE43922 | Up | 0.0795494804 |
| GSE24585 | Down | -0.1338229743 |
| GSE37065 | Down | -0.0696718705 |
| GSE28863_A1 | Down | -0.1092565476 |
| GSE28863_A2 | Up | 0.1356204295 |
| GSE28863_A3 | Up | 0.4852646883 |
| GSE28863_A4 | Up | 0.1342235419 |
| GSE48662 | Up | 0.0080463853 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
