HCSGD entry for KAT8

1. General information

Official gene symbolKAT8
Entrez ID84148
Gene full nameK(lysine) acetyltransferase 8
Other gene symbolsMOF MYST1 ZC2HC8 hMOF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000123Histone acetyltransferase complexIDAcellular_component
GO:0000776KinetochoreIEAcellular_component
GO:0004402Histone acetyltransferase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0008134Transcription factor bindingIDAmolecular_function
GO:0016407Acetyltransferase activityIDAmolecular_function
GO:0016573Histone acetylationIDAbiological_process
GO:0016747Transferase activity, transferring acyl groups other than amino-acyl groupsIEAmolecular_function
GO:0019899Enzyme bindingIEAmolecular_function
GO:0030099Myeloid cell differentiationIDAbiological_process
GO:0035064Methylated histone residue bindingIDAmolecular_function
GO:0043981Histone H4-K5 acetylationIDAbiological_process
GO:0043982Histone H4-K8 acetylationIDAbiological_process
GO:0043984Histone H4-K16 acetylationIDA IMPbiological_process
GO:0043995Histone acetyltransferase activity (H4-K5 specific)IDAmolecular_function
GO:0043996Histone acetyltransferase activity (H4-K8 specific)IDAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046972Histone acetyltransferase activity (H4-K16 specific)IDAmolecular_function
GO:0071339MLL1 complexIDAcellular_component
GO:0072487MSL complexIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95153752900.15166921090.99999024730.7522598192

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0233671081
GSE13712_SHEARDown-0.0484761837
GSE13712_STATICDown-0.2469785241
GSE19018Up0.2080368370
GSE19899_A1Down-0.2942466981
GSE19899_A2Down-0.0265783009
PubMed_21979375_A1Up0.3047018396
PubMed_21979375_A2Down-0.3287231617
GSE35957Down-0.2243609517
GSE36640Down-0.3097617698
GSE54402Down-0.1380812922
GSE9593Down-0.1974787137
GSE43922Down-0.2405213803
GSE24585Down-0.2700842032
GSE37065Up0.0502646674
GSE28863_A1Up0.0624246441
GSE28863_A2Down-0.0594476847
GSE28863_A3Down-0.3539356507
GSE28863_A4Up0.0333152276
GSE48662Up0.2530140906

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21746928Given the reversible nature of epigenetic changes, rescue experiments performed either by Mof overexpression or by histone deacetylase inhibition promoted repair protein recruitment to DNA damage sites and substantially ameliorated aging-associated phenotypes, both in vitro and in vivo
17135209The MRG15 chromo domain consists of a beta-barrel and a long alpha-helix and assumes a structure more similar to the Drosophila MOF chromo barrel domain than the typical HP1/Pc chromo domains
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