HCSGD entry for SPOP
1. General information
| Official gene symbol | SPOP |
|---|---|
| Entrez ID | 8405 |
| Gene full name | speckle-type POZ protein |
| Other gene symbols | BTBD32 TEF2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001085 | RNA polymerase II transcription factor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0031463 | Cul3-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6103856312 | 0.1809199916 | 0.9999902473 | 0.8241597612 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4474068879 |
| GSE13712_SHEAR | Up | 0.1537256643 |
| GSE13712_STATIC | Down | -0.1431930557 |
| GSE19018 | Down | -0.1793010267 |
| GSE19899_A1 | Up | 0.1311567771 |
| GSE19899_A2 | Up | 0.0523925764 |
| PubMed_21979375_A1 | Up | 0.0294283904 |
| PubMed_21979375_A2 | Up | 0.1648795408 |
| GSE35957 | Down | -0.0673409559 |
| GSE36640 | Down | -0.2895314779 |
| GSE54402 | Down | -0.0128949132 |
| GSE9593 | Down | -0.0302409995 |
| GSE43922 | Up | 0.1113164903 |
| GSE24585 | Up | 0.5668056637 |
| GSE37065 | Down | -0.1074227250 |
| GSE28863_A1 | Up | 0.0098378465 |
| GSE28863_A2 | Down | -0.1638693426 |
| GSE28863_A3 | Down | -1.0779710990 |
| GSE28863_A4 | Up | 0.1787381500 |
| GSE48662 | Up | 0.0270374972 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26527005 | SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase |
| 26527005 | However, the mechanisms by which SPOP functions as a tumor suppressor remain poorly understood |
| 26527005 | Here, we show that SPOP promotes senescence, an important tumor suppression mechanism, by targeting the SENP7 deSUMOylase for degradation |
| 26527005 | SPOP is upregulated during senescence |
| 26527005 | Ectopic wild-type SPOP, but not its cancer-associated mutants, drives senescence |
| 26527005 | Conversely, SPOP knockdown overcomes senescence |
| 26527005 | Furthermore, SENP7 is expressed at higher levels in prostate tumor specimens with SPOP mutation (n = 13) compared to those with wild-type SPOP (n = 80) |
| 26527005 | In summary, SPOP acts as a tumor suppressor by promoting senescence through degrading SENP7 |
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