HCSGD entry for RASSF4
1. General information
| Official gene symbol | RASSF4 |
|---|---|
| Entrez ID | 83937 |
| Gene full name | Ras association (RalGDS/AF-6) domain family member 4 |
| Other gene symbols | AD037 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007165 | Signal transduction | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7692479123 | 0.1282185821 | 0.9999902473 | 0.6900829892 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0382578965 |
| GSE13712_SHEAR | Down | -0.0617090190 |
| GSE13712_STATIC | Down | -0.1531317468 |
| GSE19018 | Up | 0.1361495433 |
| GSE19899_A1 | Down | -0.0943887130 |
| GSE19899_A2 | Down | -0.5660359821 |
| PubMed_21979375_A1 | Down | -0.8474444085 |
| PubMed_21979375_A2 | Down | -0.5519170397 |
| GSE35957 | Up | 0.0340813265 |
| GSE36640 | Up | 0.1086406835 |
| GSE54402 | Down | -0.5034411814 |
| GSE9593 | Down | -0.0856027825 |
| GSE43922 | Down | -0.9997902454 |
| GSE24585 | Up | 0.1703903618 |
| GSE37065 | Up | 0.1252575147 |
| GSE28863_A1 | Up | 0.3586617807 |
| GSE28863_A2 | Up | 0.2322576603 |
| GSE28863_A3 | Up | 0.1698138134 |
| GSE28863_A4 | Up | 0.0638302827 |
| GSE48662 | Up | 0.0271722538 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24334454 | We have now found that this bypass occurs in part through PAX3-FOXO1-mediated upregulation of RASSF4, a Ras-association domain family (RASSF) member |
| 24334454 | RASSF4 expression was upregulated in PAX3-FOXO1-positive aRMS cell lines and tumors |
| 24334454 | Enhanced RASSF4 expression promoted cell cycle progression, senescence evasion, and tumorigenesis through inhibition of the Hippo pathway tumor suppressor MST1 |
| 24334454 | This work provides evidence for Hippo pathway suppression in aRMS and demonstrates a progrowth role for RASSF4 |
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