HCSGD entry for CASP6
1. General information
Official gene symbol | CASP6 |
---|---|
Entrez ID | 839 |
Gene full name | caspase 6, apoptosis-related cysteine peptidase |
Other gene symbols | MCH2 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0004197 | Cysteine-type endopeptidase activity | IEA TAS | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005634 | Nucleus | IDA | cellular_component |
GO:0005654 | Nucleoplasm | TAS | cellular_component |
GO:0005730 | Nucleolus | IDA | cellular_component |
GO:0005737 | Cytoplasm | IDA | cellular_component |
GO:0005829 | Cytosol | IDA TAS | cellular_component |
GO:0006508 | Proteolysis | IDA IEA | biological_process |
GO:0006915 | Apoptotic process | IEA TAS | biological_process |
GO:0006921 | Cellular component disassembly involved in execution phase of apoptosis | TAS | biological_process |
GO:0008234 | Cysteine-type peptidase activity | TAS | molecular_function |
GO:0042802 | Identical protein binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.9972860454 | 0.0010884693 | 0.9999902473 | 0.0626905908 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Down | -0.1696382801 |
GSE13712_SHEAR | Down | -0.1419793987 |
GSE13712_STATIC | Up | 0.0426549469 |
GSE19018 | Down | -0.2720527176 |
GSE19899_A1 | Down | -0.9043309526 |
GSE19899_A2 | Down | -1.5201168143 |
PubMed_21979375_A1 | Down | -1.1538125463 |
PubMed_21979375_A2 | Down | -2.2846577854 |
GSE35957 | Down | -0.7751501758 |
GSE36640 | Down | -1.3009670512 |
GSE54402 | Down | -0.4491813097 |
GSE9593 | Down | -0.5428772664 |
GSE43922 | Down | -0.8546643169 |
GSE24585 | Up | 0.0888291813 |
GSE37065 | Down | -0.1464628861 |
GSE28863_A1 | Up | 0.3265817885 |
GSE28863_A2 | Down | -0.0211038504 |
GSE28863_A3 | Down | -0.9416434831 |
GSE28863_A4 | Down | -0.3307791647 |
GSE48662 | Down | -0.2992027124 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
---|---|---|---|---|---|---|---|
hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 18056640 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
18952756 | Expression of downstream apoptotic/stress markers, including caspase-3, caspase-6, Bax, and HSP-25, was also observed in telomerase-null, but not wild-type, AEC2 |
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