HCSGD entry for CASP6


1. General information

Official gene symbolCASP6
Entrez ID839
Gene full namecaspase 6, apoptosis-related cysteine peptidase
Other gene symbolsMCH2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004197Cysteine-type endopeptidase activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0006508ProteolysisIDA IEAbiological_process
GO:0006915Apoptotic processIEA TASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0008234Cysteine-type peptidase activityTASmolecular_function
GO:0042802Identical protein bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99728604540.00108846930.99999024730.0626905908

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1696382801
GSE13712_SHEARDown-0.1419793987
GSE13712_STATICUp0.0426549469
GSE19018Down-0.2720527176
GSE19899_A1Down-0.9043309526
GSE19899_A2Down-1.5201168143
PubMed_21979375_A1Down-1.1538125463
PubMed_21979375_A2Down-2.2846577854
GSE35957Down-0.7751501758
GSE36640Down-1.3009670512
GSE54402Down-0.4491813097
GSE9593Down-0.5428772664
GSE43922Down-0.8546643169
GSE24585Up0.0888291813
GSE37065Down-0.1464628861
GSE28863_A1Up0.3265817885
GSE28863_A2Down-0.0211038504
GSE28863_A3Down-0.9416434831
GSE28863_A4Down-0.3307791647
GSE48662Down-0.2992027124

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-125b-5pMIMAT0000423NAhsa-miR-125b18056640
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18952756Expression of downstream apoptotic/stress markers, including caspase-3, caspase-6, Bax, and HSP-25, was also observed in telomerase-null, but not wild-type, AEC2
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