HCSGD entry for MIXL1

1. General information

Official gene symbolMIXL1
Entrez ID83881
Gene full nameMix paired-like homeobox
Other gene symbolsMILD1 MIX MIXL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000790Nuclear chromatinISScellular_component
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingISSmolecular_function
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingISSmolecular_function
GO:0000987Core promoter proximal region sequence-specific DNA bindingISSmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISSmolecular_function
GO:0001085RNA polymerase II transcription factor bindingISSmolecular_function
GO:0001103RNA polymerase II repressing transcription factor bindingIPImolecular_function
GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptionISSmolecular_function
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISSmolecular_function
GO:0002244Hematopoietic progenitor cell differentiationISSbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0007369GastrulationISSbiological_process
GO:0007492Endoderm developmentISSbiological_process
GO:0007507Heart developmentISSbiological_process
GO:0035987Endodermal cell differentiationISSbiological_process
GO:0042074Cell migration involved in gastrulationIEAbiological_process
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0048565Digestive tract developmentISSbiological_process
GO:1901533Negative regulation of hematopoietic progenitor cell differentiationISSbiological_process
GO:2000382Positive regulation of mesoderm developmentISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.73833902970.65982433040.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0183928398
GSE13712_SHEARUp0.0764776984
GSE13712_STATICDown-0.0181618527
GSE19018Up0.0440627271
GSE19899_A1Down-0.1010701378
GSE19899_A2Up0.2521480036
PubMed_21979375_A1Down-0.1229121080
PubMed_21979375_A2Down-0.1117184325
GSE35957Up0.3944552801
GSE36640Up0.0337049824
GSE54402Down-0.0257107221
GSE9593Down-0.1735782289
GSE43922Up0.0562445777
GSE24585Up0.1946520327
GSE37065Up0.0010740544
GSE28863_A1Down-0.0373752581
GSE28863_A2Down-0.0152198572
GSE28863_A3Up0.0037569625
GSE28863_A4Down-0.1215330333
GSE48662Down-0.1176256729

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-145-5pMIMAT0000437MIRT021535Reporter assay;MicroarrayFunctional MTI21351259
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.