HCSGD entry for ATG10
1. General information
| Official gene symbol | ATG10 |
|---|---|
| Entrez ID | 83734 |
| Gene full name | autophagy related 10 |
| Other gene symbols | APG10 APG10L pp12616 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006497 | Protein lipidation | IEA ISS | biological_process |
| GO:0006914 | Autophagy | IMP | biological_process |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0019777 | Atg12 ligase activity | IEA ISS | molecular_function |
| GO:0031401 | Positive regulation of protein modification process | IEA ISS | biological_process |
| GO:0032446 | Protein modification by small protein conjugation | IDA | biological_process |
| GO:0034263 | Autophagy in response to ER overload | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8883030774 | 0.0265867520 | 0.9999902473 | 0.3120562834 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2680591078 |
| GSE13712_SHEAR | Up | 0.4734177401 |
| GSE13712_STATIC | Up | 0.5424334379 |
| GSE19018 | Up | 0.1015304114 |
| GSE19899_A1 | Up | 0.0208771934 |
| GSE19899_A2 | Down | -0.5725845569 |
| PubMed_21979375_A1 | Down | -1.0335419509 |
| PubMed_21979375_A2 | Down | -0.6947938580 |
| GSE35957 | Down | -0.1876382329 |
| GSE36640 | Up | 0.0192786380 |
| GSE54402 | Down | -0.2985339781 |
| GSE9593 | Down | -0.0123538437 |
| GSE43922 | Down | -1.0074823914 |
| GSE24585 | Up | 0.1905019721 |
| GSE37065 | Up | 0.1413986660 |
| GSE28863_A1 | Down | -0.2602992909 |
| GSE28863_A2 | Down | -0.1710806311 |
| GSE28863_A3 | Down | -0.5804980549 |
| GSE28863_A4 | Down | -0.2741629585 |
| GSE48662 | Down | -0.0001629035 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-9-5p | MIMAT0000441 | MIRT021335 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024684 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025071 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026156 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23451179 | The activation occurred through Sox2-mediated ATG10 gene expression and resulted in the inhibition of cell proliferation and anchorage-independent colony growth ex vivo and tumor growth in vivo |
| 23451179 | Notably, knockdown of ATG10 in Sox2-expressing colon cancer cells restored cancer cell properties |
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