HCSGD entry for YPEL3
1. General information
| Official gene symbol | YPEL3 |
|---|---|
| Entrez ID | 83719 |
| Gene full name | yippee-like 3 (Drosophila) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005730 | Nucleolus | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2110042552 | 0.1736289655 | 0.8847969890 | 0.8070082995 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1383307981 |
| GSE13712_SHEAR | Down | -0.1040892458 |
| GSE13712_STATIC | Down | -0.5555642984 |
| GSE19018 | Up | 0.2614151367 |
| GSE19899_A1 | Down | -0.0599942880 |
| GSE19899_A2 | Down | -0.1639013999 |
| PubMed_21979375_A1 | Down | -0.5549779747 |
| PubMed_21979375_A2 | Down | -0.1247664681 |
| GSE35957 | Up | 0.3092637700 |
| GSE36640 | Up | 0.4690322152 |
| GSE54402 | Down | -0.0775393128 |
| GSE9593 | Down | -0.0224379561 |
| GSE43922 | Down | -0.3990219185 |
| GSE24585 | Up | 1.4813320985 |
| GSE37065 | Down | -0.2429905037 |
| GSE28863_A1 | Down | -0.1203155840 |
| GSE28863_A2 | Down | -0.1764404959 |
| GSE28863_A3 | Up | 0.2304595057 |
| GSE28863_A4 | Down | -0.0704646878 |
| GSE48662 | Up | 0.8806367544 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017916 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21671470 | Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence |
| 21671470 | Here, we identify YPEL3 as a growth suppressive protein downregulated by estrogen in estrogen receptor positive breast cancer cell lines |
| 21671470 | Estrogen repression of YPEL3 expression was found to be independent of p53 but dependent on estrogen receptor alpha expression |
| 21671470 | Importantly, YPEL3 expression, which is induced by the removal of estrogen or treatment with tamoxifen triggers cellular senescence in MCF-7 cells while loss of YPEL3 increases the growth rate of MCF-7 cells |
| 21671470 | Taken together these findings suggest that YPEL3 may represent a potential target for directed hormonal therapy for estrogen receptor positive breast cancer patients |
| 21267786 | Senescence-associated gene YPEL3 is downregulated in human colon tumors |
| 21267786 | BACKGROUND: Previous work has demonstrated YPEL3 to be a growth-suppressive protein that acts through a pathway of cellular senescence |
| 21267786 | We set out to determine whether human colon tumors demonstrated downregulation of YPEL3 |
| 21267786 | METHODS: We collected colon tumor samples with matched normal control samples and analyzed them for YPEL3 gene expression by reverse transcriptase-polymerase chain reaction and CpG hypermethylation of the YPEL3 promoter by base-specific polymerase chain reaction analysis |
| 21267786 | Colon cancer cell lines (Caco-2 and HCT116(-/-) p53) were used to assess YPEL3 gene expression after treatment with 5-azadeoxycytidine or trichostatin A |
| 21267786 | RESULTS: Reverse transcriptase-polymerase chain reaction analysis demonstrated a decrease in YPEL3 expression in tumor samples when compared to their patient-matched normal tissue |
| 21267786 | We determined that DNA methylation of the YPEL3 promoter CpG island does not play a role in YPEL3 regulation in human colon tumors or colon cancer cells lines, consistent with the inability of 5-azadeoxycytidine treatment to induce YPEL3 expression in colon cancer cell lines |
| 21267786 | In contrast, colon cell line results suggest that histone acetylation may play a role in YPEL3 regulation in colon cancer |
| 21267786 | CONCLUSIONS: YPEL3 is preferentially downregulated in human colon adenocarcinomas |
| 21267786 | DNA hypermethylation does not appear to be the mechanism of YPEL3 downregulation in this subset of collected patient samples or in colon cell lines |
| 21267786 | Histone acetylation may be a relevant epigenetic modulator of YPEL3 in colon adenocarcinomas |
| 21267786 | Future investigation of YPEL3 and its role in colon cancer signaling and development may lead to increased understanding and alternative treatment options for this disease |
| 21196260 | Why YPEL3 represents a novel tumor suppressor |
| 21196260 | Yippee-like 3 (YPEL3) was reported in 2004 as one of five family members of the Yippee protein with conservation in species down to slime molds |
| 21196260 | While reports of other YPEL family members have surfaced our laboratory was the first to report that YPEL3 is induced by the p53 tumor suppressor |
| 21196260 | Furthermore we demonstrated that YPEL3 is growth suppressive, triggering cellular senescence in human cell lines and is down-regulated in several human tumors |
| 21196260 | Studies with mouse YPEL3, originally named small unstable apoptotic protein (SUAP), confirmed that the gene encodes a growth suppressive highly unstable protein |
| 21196260 | While there are several reported YPEL3 transcripts and potentially 2 protein isoforms, no clear protein structure has been reported |
| 21196260 | As evidence mounts that YPEL3 is a tumor suppressor gene, studies aimed at understanding its biological function, regulation of gene expression and impact on tumorigenesis will help |
| 20388804 | YPEL3, a p53-regulated gene that induces cellular senescence |
| 20388804 | In microarray studies in which p53 was reactivated in MCF7 cells, we discovered that Yippee-like-3 (YPEL3), a member of a recently discovered family of putative zinc finger motif coding genes consisting of YPEL1-5, is a p53-regulated gene |
| 20388804 | YPEL3 expression induced by DNA damage leads to p53 recruitment to a cis-acting DNA response element located near the human YPEL3 promoter |
| 20388804 | Physiologic induction of YPEL3 results in a substantial decrease in cell viability associated with an increase in cellular senescence |
| 20388804 | Consistent with its growth suppressive activity, YPEL3 gene expression is repressed in ovarian tumor samples |
| 20388804 | One mechanism of YPEL3 downregulation in ovarian tumor cell lines seems to be hypermethylation of a CpG island upstream of the YPEL3 promoter |
| 20388804 | We believe these findings point to YPEL3 being a novel tumor suppressor, which upon induction triggers a permanent growth arrest in human tumor and normal cells |
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