HCSGD entry for CASP4
1. General information
| Official gene symbol | CASP4 |
|---|---|
| Entrez ID | 837 |
| Gene full name | caspase 4, apoptosis-related cysteine peptidase |
| Other gene symbols | ICE(rel)II ICEREL-II ICH-2 Mih1/TX TX |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004197 | Cysteine-type endopeptidase activity | IEA | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0042981 | Regulation of apoptotic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0129268265 | 0.9800490027 | 0.2838087573 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4556031842 |
| GSE13712_SHEAR | Down | -0.1195935666 |
| GSE13712_STATIC | Down | -0.0669012462 |
| GSE19018 | Down | -0.2153254499 |
| GSE19899_A1 | Up | 0.4765350350 |
| GSE19899_A2 | Up | 0.5073579397 |
| PubMed_21979375_A1 | Up | 0.9091617471 |
| PubMed_21979375_A2 | Up | 0.7539930738 |
| GSE35957 | Down | -0.2868322211 |
| GSE36640 | Up | 0.8344807721 |
| GSE54402 | Up | 0.5773532685 |
| GSE9593 | Up | 0.1702694158 |
| GSE43922 | Up | 0.4021848002 |
| GSE24585 | Up | 0.5292623029 |
| GSE37065 | Up | 0.1937962792 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.1573299323 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030229 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
