HCSGD entry for CASP2
1. General information
| Official gene symbol | CASP2 |
|---|---|
| Entrez ID | 835 |
| Gene full name | caspase 2, apoptosis-related cysteine peptidase |
| Other gene symbols | CASP-2 ICH1 NEDD-2 NEDD2 PPP1R57 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001554 | Luteolysis | IEA | biological_process |
| GO:0003407 | Neural retina development | IEA | biological_process |
| GO:0004197 | Cysteine-type endopeptidase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006915 | Apoptotic process | NAS | biological_process |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | IMP | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0008630 | Intrinsic apoptotic signaling pathway in response to DNA damage | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016485 | Protein processing | IDA | biological_process |
| GO:0019899 | Enzyme binding | ISS | molecular_function |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0035234 | Ectopic germ cell programmed cell death | IEA | biological_process |
| GO:0042981 | Regulation of apoptotic process | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IDA | biological_process |
| GO:0043281 | Regulation of cysteine-type endopeptidase activity involved in apoptotic process | TAS | biological_process |
| GO:0043525 | Positive regulation of neuron apoptotic process | IEA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0071260 | Cellular response to mechanical stimulus | IEP | biological_process |
| GO:0097153 | Cysteine-type endopeptidase activity involved in apoptotic process | IEA | molecular_function |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
| GO:0097192 | Extrinsic apoptotic signaling pathway in absence of ligand | IEA | biological_process |
| GO:0097194 | Execution phase of apoptosis | TAS | biological_process |
| GO:2001235 | Positive regulation of apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9641054747 | 0.0620189886 | 0.9999902473 | 0.4696207710 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0111297834 |
| GSE13712_SHEAR | Down | -0.1471514272 |
| GSE13712_STATIC | Down | -0.1911900825 |
| GSE19018 | Down | -0.2643769788 |
| GSE19899_A1 | Down | -0.1791173919 |
| GSE19899_A2 | Down | -0.4465194622 |
| PubMed_21979375_A1 | Down | -0.1845313769 |
| PubMed_21979375_A2 | Down | -0.5593721427 |
| GSE35957 | Down | -0.2228955960 |
| GSE36640 | Down | -1.2024278743 |
| GSE54402 | Up | 0.0587375450 |
| GSE9593 | Down | -0.0916223559 |
| GSE43922 | Up | 0.1193111759 |
| GSE24585 | Up | 0.0968325288 |
| GSE37065 | Down | -0.0238498301 |
| GSE28863_A1 | Down | -0.0279112652 |
| GSE28863_A2 | Up | 0.3395516984 |
| GSE28863_A3 | Down | -0.4939288407 |
| GSE28863_A4 | Down | -0.2068434060 |
| GSE48662 | Down | -0.0849221641 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-93-3p | MIMAT0004509 | MIRT038813 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-421 | MIMAT0003339 | MIRT039414 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT044168 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25114039 | Compelling evidences suggest a tumor suppressive activity of caspase-2, eventually independently of its effect on cell death |
| 25114039 | Indeed, we have demonstrated in vitro and in vivo that loss of function of caspase-2 allows to escape oncogenic stress induced senescence |
| 25114039 | These results are discussed in the context of known tumor suppressive activity of caspase-2 |
| 17145870 | Interestingly, activation of the mitochondrial pathway, including caspase-2 processing, depolarization of the outer mitochondrial membrane, and cytochrome c release, was achieved by IR in both cell lines, indicating that p21 inhibits an event downstream of mitochondria but preceding caspase-9 activation |
| 16319532 | Significant activation of caspase-2 and caspase-3 was only observed in MDA-MB-231 cells treated with doxorubicin but not with WP631, indicating that caspases may be not mandatory for the occurrence of cell death through mitotic catastrophe |
| 10438583 | When all the clones were treated with anti-Fas the processing of caspase-2, -3, and -7 but not -8 was inhibited in the resistant clones to a similar extent by the differential overexpression of Bcl-2 |
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